Application value of urine kidney injury molecule-1 in early evaluating the renal function for unilateral obstruction renal disease

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Objective To study the early renal function assessment value of urine kidney injury molecule-1 (KIM-1) level in patients with unilateral obstruction renal diseases. Methods Seventy-eight patients with unilateral obstruction renal diseases were selected, and the glomerular filtration rate (GFR) was detected by 99Tcm-diethylene triaminepentaacetic acid (DTPA) renal dynamic imaging method. The patients were divided into 4 groups according to the GFR: normal renal function group with GFR>40 ml/(min·1.73 m2) 25 cases (A group), low-injury renal function group with 20 ml/(min·1.73 m2) 0.05). The KIM-1 was negatively correlated with GFR (r=-0.441, P 0.05). The receiver operating characteristic curve analysis result showed that the area under curve of urine KIM-1 in the diagnosis of kidney injury was significantly higher than that in serum creatinine and blood urea nitrogen (0.804 vs. 0.441 and 0.567); the sensitivity and specificity were 82.6% and 66.7%, 56.5% and 53.3%, 66.9% and 66.7%. Conclusions The expression level of urine KIM-1 of unilateral obstructive nephropathy with different degree of kidney injury is a higher sensitivity marker compared with serum creatinine and blood urea nitrogen, which is helpful for diagnosing kidney injury early in clinic. Key words: Nephrosis; Glomerular filtration rate; Kidney function tests; Kidney injury molecule-1

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