Synthesis of Zinc Oxide Eudragit FS30D Nanohybrids: Structure, Characterization, and Their Application as an Intestinal Drug Delivery System
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Le résumé fourni par la source
The present study was designed to develop multifunctional zinc oxide-encapsulated Eudragit FS30D (ZnO/EFS) nanohybrid structures as a biodegradable drug delivery system and as a promising successful carrier for targeting sites. The solvent evaporation method was used to fabricate the ZnO/EFS nanohybrids and the size, shape, stability, and antioxidant activity were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and an antioxidant (1,1-diphenyl-2-picrylhydrazyl (DPPH)). Zinc oxide-encapsulated Eudragit FS30D (ZnO/EFS) nanohybrid structures consisted of irregularly shaped, 297.65 nm-sized ZnO/EFS microcapsule, enduring thermal stability from 251.17 to 385.67 °C. Nano-ZnO was encapsulated in EFS through the formation of hydrogen bonds, and the average encapsulation efficiency for nano-ZnO was determined to be 96.12%. In vitro intestinal-targeted drug release assay provided 91.86% with free nano-ZnO, only 9.5% in acidified ZnO/EFS nanohybrid structure but the rate ZnO/EFS nanohybrids reached 93.11% in succus entericus resultantly modified nano-ZnO was proven proficient intestinal-specific delivery system. The stability of the ZnO/EFS nanohybrid structures was confirmed using ζ-potential and antioxidant activity analysis. Hence, the EFS nanoencapsulation strategy of ZnO provided a stable, nontoxic, and pharmacokinetically active intestine-specific system that can become the best choice for an effective oral feed additive in future.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Synthesis of Zinc Oxide Eudragit FS30D Nanohybrids: Structure, Characterization, and Their Application as an Intestinal Drug Delivery System
- Date Crossref
- 13/05/2020
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Zhongkai University of Agriculture and Engineering pays non établi dans la noticeUniversité ou école supérieure
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City University of Hong Kong pays non établi dans la noticeUniversité ou école supérieure
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Islamia University of Bahawalpur Department of Biochemistry & Biotechnology (Baghdad-ul-Jadeed Campus) pays non établi dans la noticeUniversité ou école supérieure
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Key Laboratory of Guangdong Province pays non établi dans la noticeStructure de recherche
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School of Chemistry and Chemical Engineering pays non établi dans la noticeUniversité ou école supérieure
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School of Energy and Environment and State Key Laboratory of Marine Pollution pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Province Key Laboratory of Waterfowl Healthy Breeding pays non établi dans la noticeStructure de recherche
Zhongkai University of Agriculture and Engineering, City University of Hong Kong et Department of Biochemistry & Biotechnology (Baghdad-ul-Jadeed Campus) — Islamia University of Bahawalpur, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.