Translational Medicine – A Paradigm Shift in Modern Drug Discovery and Development

Le résumé fourni par la source

Biomarkers are the stepping-stones for modern drug discovery and development. Translational medicine and biomarkers research have taken center stage in validation of the molecular target for pharmaceutical exploitation. This chapter offers a utilitarian approach to biomarkers and target selection and validation that is driven by the translational medicine prospect of the target to become a successful drug target. It provides clear definitions of the type of biomarkers that are the core of translational medicine and biomarkers research in modern pharmaceutical companies. The chapter also offers classification and analytical process aimed to assess risk, innovation, feasibility, and predictability of success of translating novel targets into successful drugs. They are disease-specific target, target present physiologically in a nonactive form but is activated and contributes to the disease, target functions physiologically but in an augmented, uncontrolled fashion that contributes to the disease, and target maintains physiological functions in normal and disease states.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.