DRUG USE AT CLINICAL HOSPITAL STIP-EVALUATION OF RATIONAL/IRRATIONAL USE

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Introduction-According to WHO, rational use of medicines is defined as process that allows prescribing of the right drug fora right patient in the proper dose, duration of therapy, with the lowest cost for the patient and the community. Irrational drug use represents a major generator of progressively increasing costs in all health systems. (Holloway and Green, 2003).The aim of this study was to evaluate rational/irrational drug use at orthopedic department at Clinical HospitalStip.Materials and methods-A retrospective evaluation for the period of 6 monthsconcerning to consumption of analgesics (Tramadol andKetoprofen) and antibiotics (Ceftriaxon), was done. Totalnumber of patients was 528 in evaluated period January-June 2015. The Evaluation of the therapy used in thestudy was according to the guidelines for evidence-basedmedicine issued by the Ministry of Health of RM for thetreatment of diseases that are diagnosed in the test population. Inorder to detect discrepancies in the rational drug use foreach of the evaluated drugs, DDD expressed per 100 hospital beds was calculated. The obtained data were statistically analyzed using SPSS.v.20 software licensed program.Results and discussion-In Clinical hospital – Stip, annually expenditure fordrugs is 500 000.00 euros and 7.1% belongs to the orthopedic department. 528 hospitalized patients in this department wereincluded.The average age of evaluated patientswas 57.14 ± 20.3 years and average time of hospitalization per patient was 7.74 ± 10.4 days. In most of the hospitalized patients diagnose was bone fracture and almostall patients received more than 4 drugs as parenteral therapy. The most commonly used analgesic for the pain controltreatment were Amp. Ketoprofen and Tramadol and thay were applied inalmost all patients much longer thanrecommendations of 5 days Regarding to the use of antibiotics for prophylaxis inorthopedic patients we found that ceftriaxone was mostlyused antibiotic values for DDD/HHB from 26.24 to 42.74and in all evaluated period the period of using of this antibiotic was more than 2 days.Conclusion-Evaluation of the drug consumption at orthopedic department at Clinical Hospital Stip indicates irrational druguse in terms of all monitored indicators and recommendations for rational use of medicines. proper dose, duration of therapy, with the lowest cost for the patient and thecommunity.

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