[Histologic kidney lesions during pure nephrotic syndrome in adults in Conakry].
Rattachement africain : Guinée, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: Nephrotic syndrome represents a significant part of chronic kidney disease in Black Africa. Our work aimed to determine the frequency and type of kidney lesions in an adult carrying pure nephrotic syndrome. PATIENTS AND METHODS: We conducted a prospective and descriptive study (2003-2004), 40 patients were recruited on the basis of the presence of a pure nephrotic syndrome. Proteinuria was plentiful, selective to albumin greater than 3 g/24h, not accompanied by hematuria, or high blood pressure, or kidney failure. Cases of bacterial, parasitic and viral infections (hepatitis B, C, HIV) were excluded. By following contra-indications of renal biopsy, samples were taken under local anesthesia by means of percutaneous lumbar and fixed in two tubes, one containing "Michel's medium" and the other 12% Formalin. These techniques and readings were carried out in the pathological anatomy Laboratories of Nantes (France) and Conakry (Guinea). RESULTS: There were 24 men and 16 women with an average age of 26.2 ± 8 years [range: 20-51]. Clinical symptoms were dominated by weight gain characterized by edema. Proteinuria was between 3-3.5 g/24h in 16 (40%); between 3.6-5 g in 2 cases (5%) and greater than 5 g/24h in 22 cases (55%). The number of glomeruli was on average 11 ± 9 [range: 3-36]; glomerular permeability was on average 10.4 ± 10. Renal impairment was glomerular in 22 cases, tubulointerstitial in 12 cases and vascular in 6 cases. Immunofixation was positive in 30/40 cases for IgA IgG IgM; in 26 cases for C1q C3; in 4 cases for C1q C3 C4; and finally for fibrin in 28 cases. Histological renal lesions were FSGS (40%), MDC (35%), MGN (5%), MPGN (5%) and undetermined (15%). CONCLUSION: A regular practice of renal anatomopathological examination "on the spot" will lead us to carefully assess the causes of kidney failure associated with nephrotic syndrome.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
Où se fait cette recherche
-
Donka Hospital Guinée (code pays fourni par la source)Établissement de santé
-
Imagerie Médicale et Radiothérapie Drôme Ardèche pays non établi dans la noticeÉtablissement de santé
-
Gamal Abdel Nasser University of Conakry Gamal Abdel Nasser University of Conakry, Guinée (code pays fourni par la source)Université ou école supérieure
-
Centre Hospitalier Universitaire de Nantes pays non établi dans la noticeÉtablissement de santé
-
néphrologie hémodialyse CHU Conakry néphrologie hémodialyse CHU Conakry, Guinée (ville ou établissement reconnu, pays non nommé)Établissement de santé
-
radiologie-imagerie CHU Conakry radiologie-imagerie CHU Conakry, Guinée (ville ou établissement reconnu, pays non nommé)Établissement de santé
-
anatomie pathologique CHU Conakry anatomie pathologique CHU Conakry, Guinée (ville ou établissement reconnu, pays non nommé)Établissement de santé
-
anatomie pathologique « A » CHU Nantes pays non établi dans la noticeÉtablissement de santé
Donka Hospital (Guinée), Imagerie Médicale et Radiothérapie Drôme Ardèche et Gamal Abdel Nasser University of Conakry (Gamal Abdel Nasser University of Conakry, Guinée), avec 5 autres affiliations. Pays d’affiliation : Guinée.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.