Antioxidant and Anti‐Inflammatory Effects of Different Zinc Sources on Diquat‐Induced Oxidant Stress in a Piglet Model
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Le résumé fourni par la source
Zinc (Zn) plays a crucial role in reducing oxidative stress and diarrhea in postweanling piglets. This study is aimed at comparing the effects of zinc chelate of 2‐hydroxy‐4 methyl‐thio butanoic acid (HMZn) and ZnSO4 on the oxidative stress in weaned piglets. A total of 32 piglets were randomly divided into 4 treatments: CON: basal diet+80 mg/kg Zn as ZnSO4; DIQ: basal diet+80 mg/kg Zn as ZnSO4; HMZn: basal diet+200 mg/kg Zn as HMZn; and ZnSO4: basal diet+200 mg/kg Zn as ZnSO4. On day 15, the DIQ, HMZn, and ZnSO4 groups were injected intraperitoneally with diquat except for the CON group. The trial lasted 21 days. The results showed that zinc sources did not influence the growth performance during the first 14 days. But HMZn increased activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and total antioxidant capacity (T‐AOC) in serum (P < 0.05). After diquat injection, the fecal score was decreased in the HMZn group. Both HMZn and ZnSO4 increased the activities of GPX and T‐AOC in serum and the relative mRNA expressions of hepatic and renal Nrf2, SOD1, and GPX compared with the DIQ group (P < 0.05). Moreover, the relative mRNA expression of inflammatory factors in the small intestine, liver, and kidney was downregulated; the phosphorylation of NF‐κB protein was inhibited in the HMZn group compared with the DIQ and ZnSO4 groups (P < 0.05). In general, HMZn showed notable advantage over ZnSO4 in reducing diarrhea and improving antioxidant and anti‐inflammatory ability in piglets challenged with diquat.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Antioxidant and Anti‐Inflammatory Effects of Different Zinc Sources on Diquat‐Induced Oxidant Stress in a Piglet Model
- Date Crossref
- 01/01/2020
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hunan Agricultural University pays non établi dans la noticeUniversité ou école supérieure
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Hunan Normal University pays non établi dans la noticeUniversité ou école supérieure
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Institute of Subtropical Agriculture pays non établi dans la noticeStructure de recherche
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College of Animal Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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College of Life Sciences Hunan International Joint Laboratory of Animal Intestinal Ecology and Health pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Agriculture Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central pays non établi dans la noticeOrganisme public
Hunan Agricultural University, Hunan Normal University et Institute of Subtropical Agriculture, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.