Accès ouvert déclaré
2020
article
Persistent Disease Activity in Patients With Long-Standing Glomerular Disease
Elisa Delbarba, Maddalena Marasà, Pietro A. Canetta, Stacy Piva, Debanjana Chatterjee, Byum Hee Kil, Xueru Mu, Keisha L. Gibson, Michelle Hladunewich, Jonathan Hogan, Bruce A. Julian, Jason M. Kidd, Louis‐Philippe Laurin, Patrick H. Nachman, Michelle N. Rheault, Dana V. Rizk, Neil Sanghani, Howard Trachtman, Scott E. Wenderfer, Ali G. Gharavi, Andrew S. Bomback, Wooin Ahn, Gerald B. Appel, Revekka Babayev, Ibrahim Batal, Eric J. Brown, Eric S. Campenot, Brenda Chan, Vivette D. D’Agati, Hilda Fernández, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Krzysztof Kiryluk, Wai Lam Lau, Fangming Lin, Francesca Lugani, Glen S. Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Jai Radhakrishnan, Maya K. Rao, Simone Sanna‐Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Larry A. Greenbaum, William E. Smoyer, Amira Al‐Uzri, Isa Ashoor, Diego Avilés, Rossana Baracco, John Barcia, Sharon Bartosh, Craig W. Belsha, Corinna Bowers, Michael Braun, Aftab S. Chishti, Donna Claes, Carl H. Cramer, Keefe Davis, Elif Erkan, Daniel I. Feig, Michael Freundlich, Rasheed Gbadegesin, Melisha Hanna, Guillermo Hidalgo, Tracy E. Hunley, Amrish Jain, Mahmoud Kallash, Myda Khalid, Jon B. Klein, Jerome C. Lane, John D. Mahan, Nisha Mathews, Carla Nester, Cynthia X. Pan, Larry T. Patterson, Hiren P. Patel, Adelaide Revell, Cynthia Silva, Rajasree Sreedharan, Tarak Srivastava, Julia Steinke, Katherine Twombley, Tetyana L. Vasylyeva, Donald J. Weaver, Craig S. Wong, Salem Almaani, Isabelle Ayoub, Milos N. Budisavljevic, Vimal K. Derebail, Huma Fatima, Ronald J. Falk, Agnes B. Fogo, Todd W.B. Gehr, Dorey A. Glenn, Raymond C. Harris, Susan L. Hogan, Koyal Jain, J. Charles Jennette, H. Davis Massey, Amy K. Mottl, Tibor Nádasdy, Jan Novák, Samir M. Parikh, Vincent Pichette, Caroline J. Poulton, Thomas Brian Powell, Matthew B. Renfrow, Brad H. Rovin, Virginie Royal, Manish K. Saha, Sally Self, Sharon G. Adler, Charles E. Alpers, Raed Bou Matar, Elizabeth Brown, Daniel C. Cattran, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Alessia Fornoni, Crystal A. Gadegbeku, Patrick E. Gipson, Leah Hasely, Sangeeta Hingorani, Lawrence B. Holzman, J. Ashley Jefferson, Kenar D. Jhaveri, Duncan B. Johnstone, Frederick J. Kaskel, Amy Kogan, Jeffrey B. Kopp, Richard Lafayette, Kevin V. Lemley, Laura Málaga-Diéguez, Kevin Meyers, Alicia M. Neu, Michelle M. O’Shaughnessy, John F. O’Toole, Rulan S. Parekh, Heather N. Reich, Kimberly J. Reidy, Helbert Rondon‐Berrios, Kamalanathan K. Sambandam, John R. Sedor, David T. Selewski, Christine B. Sethna, Jeffrey R. Schelling, Katherine R. Tuttle, Joseph Weisstuch, Suzanne Vento, Olga Zhdanova, Brenda W. Gillespie, Debbie S. Gipson, Peg Hill-Callahan, Margaret Helmuth, Emily Herreshoff, Matthias Kretzler, Chrysta Lienczewski, Sarah Mansfield, Laura Mariani, Cynthia C. Nast, Bruce Robinson, Jonathan P. Troost, Matthew Wladkowski, Jarcy Zee, Dawn Zinsser, Lisa M. Guay‐Woodford
2Citations signalées, ce qui n’est pas une note de qualité
18Institutions déclarées
3Pays d’affiliation déclarés
Rattachement africain : us, it, ca.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction Glomerular diseases are characterized by variable disease activity over many years. We aimed to analyze the relationship between clinical disease activity and duration of glomerular disease. Methods Disease activity in adults with chronic minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy (IgAN; first diagnostic biopsy >5 years before enrollment; Of Longstanding Disease [OLD] cohort, n = 256) followed at Columbia University Medical Center (CUMC), was compared with disease activity of an internal and external cohort of patients with first diagnostic biopsy <5 years before enrollment drawn from the Cure Glomerulonephropathy Network (CureGN cohort, n = 1182; CUMC-CureGN cohort, n = 362). Disease activity was defined by (i) Kidney Disease: Improving Global Outcomes–recommended threshold criteria for initiation of immunosuppression in primary glomerulonephropathy (GN) and (ii) CureGN's Disease Activity Working Group definitions for activity. Results No significant differences were detected among the 3 cohorts in terms of age, sex, serum creatinine, and urinary protein-to-creatinine ratio. For each GN subtype, disease activity in the OLD cohort was comparable with disease activity in the entire CureGN and the CUMC-CureGN cohort. When limiting our comparisons to disease activity in incident CUMC-CureGN patients (first diagnostic biopsy within 6 months of enrollment), OLD patients demonstrated similar activity rates as incident patients. Conclusion Disease activity did not differ among patients with shorter versus longer duration of disease. Such survivor patients, with long-term but persistent disease, are potentially highly informative for understanding the clinical course and pathogenesis of GN and may help identify factors mediating more chronic subtypes of disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Persistent Disease Activity in Patients With Long-Standing Glomerular Disease
- Date Crossref
- 01/06/2020
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Renal Diseases and GlomerulopathiesChronic Kidney Disease and DiabetesVasculitis and related conditions