The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study
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Le résumé fourni par la source
BACKGROUND: Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. Several factors that influence EE have been studied previously. However, the effect of neuromuscular blocking agents on EE, which conceptually would lower EE, has not been extensively investigated. METHODS: × 8.19). A subgroup analysis of septic and non-septic patients was performed. Furthermore, the effects of body temperature and sepsis on EE were evaluated. A secondary endpoint was hypercaloric feeding (> 110% of EE) after cisatracurium infusion. RESULTS: In total, 122 patients were included. Mean EE before cisatracurium infusion was 1974 kcal/day and 1888 kcal/day after cisatracurium infusion. Multivariable analysis showed a significantly lower EE after cisatracurium infusion (MD - 132.0 kcal (95% CI - 212.0 to - 52.0; p = 0.001) in all patients. This difference was statistically significant in both sepsis and non-sepsis patients (p = 0.036 and p = 0.011). Non-sepsis patients had lower EE than sepsis patients (MD - 120.6 kcal; 95% CI - 200.5 to - 40.8, p = 0.003). Body temperature and EE were positively correlated (Spearman's rho = 0.486, p < 0.001). Hypercaloric feeding was observed in 7 patients. CONCLUSIONS: Our data suggest that continuous infusion of cisatracurium in mechanically ventilated ICU patients is associated with a significant reduction in EE, although the magnitude of the effect is small. Sepsis and higher body temperature are associated with increased EE. Cisatracurium infusion is associated with overfeeding in only a minority of patients and therefore, in most patients, no reductions in caloric prescription are necessary.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study
- Date Crossref
- 03/02/2020
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ziekenhuis Gelderse Vallei pays non établi dans la noticeÉtablissement de santé
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Diakonessenhuis hospital pays non établi dans la noticeÉtablissement de santé
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University Medical Center Utrecht pays non établi dans la noticeÉtablissement de santé
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Gelderse Vallei Hospital Department of Intensive Care Medicine pays non établi dans la noticeÉtablissement de santé
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Department of Intensive Care Medicine pays non établi dans la noticeInstitution
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University Medical Center Amsterdam Department of Intensive Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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University Medical Centre Utrecht Department of Intensive Care Medicine pays non établi dans la noticeUniversité ou école supérieure
Ziekenhuis Gelderse Vallei, Diakonessenhuis hospital et University Medical Center Utrecht, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.