Fracture-related infections in HIV infected patients: A systematic review and meta-analysis
Rattachement africain : Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
AIM: To conduct a systematic review and meta-analysis comparing the incidence of fracture-related infections (FRI) following surgical management of closed and open fractures in HIV-positive and HIV-negative patients. METHODS: A systematic literature search was conducted using MEDLINE, ProQuest, Web of Science, The Cochrane Library and Scopus. Our own files and reference lists of identified key articles were also searched. We included studies where the primary outcome was the development of FRI in patients with open and closed fractures. RESULTS: Eleven studies were included for data synthesis. HIV-positive patients had a non-significant increase in FRI when compared to HIV-negative patients (in open and closed fractures combined). Open fractures treated in the pre-antiretroviral era had a 5.6 times greater risk for developing a FRI. In the post-antiretroviral era (1997 onwards) HIV-positive patients did not have a greater risk of FRI than HIV-negative patients for both open and closed fractures. The small retrospective natures of these studies, together with the heterogeneous outcome definitions used, are limitations to this study. CONCLUSION: While there are few large prospective studies, the available data suggests that before the introduction antiretroviral therapy HIV infection was associated with a greater risk of FRI. In the post-antiretroviral era HIV infected patients did not show an increased risk of FRI.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Fracture-related infections in HIV infected patients: A systematic review and meta-analysis
- Date Crossref
- 01/03/2020
- Éditeur
- Scientific Scholar
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Grey's Hospital Sepsis & Reconstruction Unit Pietermaritzburg, Afrique du Sud (code pays fourni par la source)Établissement de santé
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University of KwaZulu-Natal Department Anaesthetics University of KwaZulu-Natal, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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Jones Pietermaritzburg, Afrique du Sud (pays nommé en fin d’affiliation)Institution
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School of Clinical Medicine Department Orthopaedics University of KwaZulu-Natal, Afrique du Sud (pays nommé en fin d’affiliation)Université ou école supérieure
Sepsis & Reconstruction Unit — Grey's Hospital (Pietermaritzburg, Afrique du Sud), Department Anaesthetics — University of KwaZulu-Natal (University of KwaZulu-Natal, Afrique du Sud) et Jones (Pietermaritzburg, Afrique du Sud), avec 1 autre affiliation. Pays d’affiliation : Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.