Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes
Rattachement africain : Nigéria, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: To determine the accuracy of a semi-quantitative interleukin-6 (IL-6) vaginal secretion rapid test (Chorioquick) for detecting chorioamnionitis in women with premature rupture of membranes (PROM). METHODS: A prospective cohort study in five tertiary hospitals in Nigeria involved women with confirmed PROM at term and preterm PROM with or without suspected chorioamnionitis from August 1, 2017, to October 31, 2018. Cervicovaginal fluid samples were tested for chorioamnionitis using the Chorioquick test. Samples were repeated at decision to deliver. The test was considered positive if at least the indicator 'IL-6 low' of the three Chorioquick biomarkers (low, medium, high) was positive, or negative if none of the biomarkers were positive. Chorioamnionitis was histologically confirmed post-delivery using three tissue samples. Primary outcome measures were sensitivity, specificity, and accuracy. RESULTS: Of 73 women, on histological confirmation, 39 were true positive and 29 were true negative (for chorioamnionitis) to the Chorioquick test at repeat assessment. Overall, the Chorioquick test had a sensitivity of 97.5% (95% confidence interval [CI] 85.3-99.9), specificity 87.9% (70.9-96.0), and accuracy 93.2% (79.5-99.1). Sub-group analysis of women <37 weeks of pregnancy showed a sensitivity of 100.0% (95% CI 83.4-100.0), specificity of 91.3% (70.5-98.5), and accuracy of 95.8% (82.5-99.5). Triple positive samples were 100.0% specific in all gestations. CONCLUSION: Chorioquick showed favorable utility for detecting chorioamnionitis in PROM and could be a reliable, non-invasive rapid tool in a real-world clinical setting.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes
- Date Crossref
- 23/01/2020
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nnamdi Azikiwe University Department of Obstetrics and Gynecology Nnewi, Nigéria (code pays fourni par la source)Université ou école supérieure
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Nnamdi Azikiwe University Teaching Hospital Nigéria (code pays fourni par la source)Établissement de santé
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University of Nigeria Department of Obstetrics and Gynecology Enugu, Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Nigeria Teaching Hospital Nigéria (code pays fourni par la source)Établissement de santé
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Enugu State University of Science and Technology Department of Histopathology Enugu, Nigéria (code pays fourni par la source)Université ou école supérieure
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Chukwuemeka Odumegwu Ojukwu University Department of Obstetrics and Gynecology Awka, Nigéria (code pays fourni par la source)Université ou école supérieure
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Johns Hopkins University Department of Gynecology and Obstetrics pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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College of Medicine Department of Obstetrics and Gynecology University of Nigeria Enugu Campus, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Obstetrics and Gynecology — Nnamdi Azikiwe University (Nnewi, Nigéria), Nnamdi Azikiwe University Teaching Hospital (Nigéria) et Department of Obstetrics and Gynecology — University of Nigeria (Enugu, Nigéria), avec 6 autres affiliations. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.