Estudo das proteínas da transição epitélio-mesênquima na invasão óssea do carcinoma epidermóide da cavidade oral

Résumé fourni par la source

Squamous cell carcinoma is the most common cancer of the oral cavity.When the tumor invades the bone tissue, the prognostic and survival rate decreases a lot, and the treatment becomes more aggressive, with several damages to the patient and health system.Many of the molecular mechanisms of this process are not understood yet, but it's already known that one of central processes of tumor evolution -adjacent tissues invasion and metastasis -is a large spectrum of phenotypic changes in epithelial cells to mesenchymal, in a process named as epithelial-mesenchymal transition.During this phenomenon, there are a lot of changes in the cells protein expression, which can be used as biomarkers for diagnostic and determination of tumor aggressiveness in early stages, as also the possibility of developing new treatment drugs, more specific and efficient.The objective of this retrospective study is to evaluate if epithelial-mesenchymal transition is present in bone invasion of oral squamous cell carcinoma, by immunohistochemistry evaluation of E-cadherin, Twist, Vimentin, TGFβ1 and Periostin expression.The proteins expression was very heterogeneous.E-cadherin and Twist showed high levels of positivity, and were found associations between Twist positive expression and infiltrative bone invasion pattern (p=0,041), primary tumor site close to bone (p=0,014) and Periostin negative expression (p=0,031), suggesting this transcription factor could be strongly involved in the disease evolution in bone tissue.There are also associations between Vimentin expression and tumor size.The results of this study suggests that epithelial-mesenchymal transition could be present in some level of its spectrum in bone invasion of oral squamous cell carcinoma.

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