Comparative metabolic and obesity profiles of COPD and non-COPD controls in the CanCOLD population-based cohort

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Rationale: A high prevalence of metabolic syndrome and obesity in patients with chronic obstructive pulmonary disease (COPD) has suggested pathophysiological links between these disorders. However, whether differences in metabolic profiles and accumulation in ectopic adipose tissue exist between COPD and non COPD subjects remains unclear. Objective: To compare the metabolic profile (insulin resistance, adipokines, lipids), and visceral adipose tissue accumulation between subjects with COPD and controls in a population-based cohort. Methods: 263 subjects were randomly selected from the general population and prospectively classified according to the GOLD classification. Blood was collected and a computed tomography obtained to quantify insulin resistance (HOMA-IR), lipid and adipokine profiles, and visceral adipose tissue cross-sectional areas (VAT CSA) assessed at L4-L5. Results: 144 COPD (70 GOLD 1 and 74 GOLD 2+) and 119 non-COPD controls were included. No specific distributions of metabolic parameters and adipokines appears in graphical representations between COPD and controls. No increased Odds-Ratios for having pathologic profiles of HOMA-IR, lipids and VAT were observed in COPD subjects on multivariate analyses taking into account age, sex, body mass index, tobacco status and current medications. Conclusion: In a population-based population, no differences were found in metabolic profiles and ectopic fat accumulation between COPD and non-COPD subjects. Increased prevalence of abnormal metabolic profile and ectopic fat accumulation found in previous studies could be related to the inclusion of specific COPD phenotypes at higher risk of metabolic disturbances.

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