Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population
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Le résumé fourni par la source
INTRODUCTION: We set out to evaluate the performance of a multitarget stool DNA (MT-sDNA) in an average-risk colonoscopy-controlled colorectal cancer (CRC) screening population. MT-sDNA stool test results were evaluated against fecal immunochemical test (FIT) results for the detection of different lesions, including molecularly defined high-risk adenomas and several other tumor characteristics. METHODS: Whole stool samples (n = 1,047) were prospectively collected and subjected to an MT-sDNA test, which tests for KRAS mutations, NDRG4 and BMP3 promoter methylation, and hemoglobin. Results for detecting CRC (n = 7), advanced precancerous lesions (advanced adenoma [AA] and advanced serrated polyps; n = 119), and non-AAs (n = 191) were compared with those of FIT alone (thresholds of 50, 75, and 100 hemoglobin/mL). AAs with high risk of progression were defined by the presence of specific DNA copy number events as measured by low-pass whole genome sequencing. RESULTS: The MT-sDNA test was more sensitive than FIT alone in detecting advanced precancerous lesions (46% (55/119) vs 27% (32/119), respectively, P < 0.001). Specificities among individuals with nonadvanced or negative findings (controls) were 89% (791/888) and 93% (828/888) for MT-sDNA and FIT testing, respectively. A positive MT-sDNA test was associated with multiple lesions (P = 0.005), larger lesions (P = 0.03), and lesions with tubulovillous architecture (P = 0.04). The sensitivity of the MT-sDNA test or FIT in detecting individuals with high-risk AAs (n = 19) from individuals with low-risk AAs (n = 52) was not significantly different. DISCUSSION: In an average-risk screening population, the MT-sDNA test has an increased sensitivity for detecting advanced precancerous lesions compared with FIT alone. AAs with a high risk of progression were not detected with significantly higher sensitivity by MT-sDNA or FIT.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population
- Date Crossref
- 25/11/2019
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Netherlands Cancer Institute Department of Pathology pays non établi dans la noticeÉtablissement de santé
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Maastricht University Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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Amsterdam UMC Location Vrije Universiteit Amsterdam pays non établi dans la noticeÉtablissement de santé
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Erasmus MC pays non établi dans la noticeÉtablissement de santé
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Amsterdam UMC Location University of Amsterdam pays non établi dans la noticeÉtablissement de santé
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Amsterdam University Medical Centers pays non établi dans la noticeÉtablissement de santé
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Exact Sciences (United States) pays non établi dans la noticeEntreprise
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Amsterdam UMC—VU University Medical Center Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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Erasmus University Medical Center Department of Gastroenterology and Hepatology pays non établi dans la noticeUniversité ou école supérieure
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Amsterdam UMC—Academic Medical Center Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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Exact Sciences Corporation pays non établi dans la noticeInstitution
Department of Pathology — The Netherlands Cancer Institute, Department of Pathology — Maastricht University et Amsterdam UMC Location Vrije Universiteit Amsterdam, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.