Alexithymia and anhedonia in early Richardson's syndrome and progressive supranuclear palsy with predominant parkinsonism
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: Phenotypic variants of progressive supranuclear palsy (PSP) are all characterized by the combination of motor symptoms of parkinsonism with a number of neuropsychiatric and cognitive disorders. Despite the strong effort in characterizing these features in PSP, alexithymia and anhedonia have not been investigated at present. Here, we aimed at investigating the qualitative and quantitative differences of alexithymia and anhedonia in the two more frequent variants of PSP, Richardson's syndrome (PSP-RS) and PSP with predominant parkinsonism (PSP-P) compared to Parkinson's disease (PD) patients recruited within 24 months after the onset of motor symptoms. METHODS: One hundred fifty-five PD, 11 PSP-P, and 14 PSP-RS patients underwent clinical, neuropsychiatric, and neuropsychological evaluations. Alexithymia was assessed using the Toronto Alexithymia Scale-20 item (TAS-20), and hedonic tone was measured by the Snaith-Hamilton Pleasure Scale (SHAPS). RESULTS: In PSP-P and PSP-RS patients, the frequency of alexithymia diagnosis was higher than in PD. On the TAS-20 scores, PSP-RS performed worse in the total score and in F2 sub-scale when compared to PD. Among patients with diagnosis of depression, PSP-RS showed higher scores in TAS-20 total and TAS-20 F2 than PD. No significant differences in TAS-20 scores were found in nondepressed patients. Finally, we did not find significant differences among PD, PSP-P, and PSP-RS groups in the SHAPS scores. CONCLUSIONS: Alexithymia is identifiable very early in PSP-P and PSP-RS patients. Alexithymic symptoms differentiate PSP-RS group from PD group but not between the two subtypes of PSP. Further, alexithymia in PSP seems to be predicted by the presence of depression. Altered emotional capability could be related to specific neurophysiological dysfunction occurring precociously in PSP; therefore, its identification could orient the diagnosis toward PSP cases.
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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Alexithymia and anhedonia in early Richardson's syndrome and progressive supranuclear palsy with predominant parkinsonism
- Date Crossref
- 19/11/2019
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Fondazione Santa Lucia pays non établi dans la noticeÉtablissement de santé
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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Ospedale di Belcolle pays non établi dans la noticeÉtablissement de santé
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Aziende Socio Sanitaria Territoriale Rhodense pays non établi dans la noticeOrganisme public
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University of Rome Tor Vergata pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera San Giovanni Addolorata pays non établi dans la noticeÉtablissement de santé
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Sapienza University of Rome pays non établi dans la noticeUniversité ou école supérieure
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UOC Neurologia Azienda Ospedaliera “Belcolle” Viterbo Italy pays non établi dans la noticeInstitution
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Centro Alzheimer ASST Rhodense Rho Italy pays non établi dans la noticeInstitution
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Dipartimento di Medicina dei Sistemi Università “Tor Vergata” Roma Italy pays non établi dans la noticeInstitution
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UOC Neurologia Azienda Ospedaliera “San Giovanni Addolorata” Roma Italy pays non établi dans la noticeInstitution
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Dipartimento di Neuroscienze Salute Mentale e Organi di Senso “Sapienza” Università di Roma Roma Italy pays non établi dans la noticeInstitution
Fondazione Santa Lucia, Istituti di Ricovero e Cura a Carattere Scientifico et Ospedale di Belcolle, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.