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2024
article
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
K. Sandow, H.J. De Silva, Annette Peters, Matthew Brown, J.D. Faul, Thomas W. Winkler, A.G. Uitterlinden, Masoud Amini, Peter Sever, Sarah E. Harris, Ubaydah Nasri, David J. Porteous, Wei Zhao, L.J. Launer, Jennifer A. Smith, J. Luan, Jing Hua Zhao, E. Evangelou, Tin Aung, Treva Rice, L.M. Rose, Lucio Milani, Jr. Mosley, Kurt K. Lohman, Erin B. Ware, T.M. Bartz, J.A. Brody, Mario Sims, W. Palmas, K.-H. Lin, Jeffery R. O’Connell, Anuradhani Kasturiratne, Miao He, J.S. Pankow, Yongjun Sung, C.-Y. Cheng, Colin A. McKenzie, Marcus Dörr, A. Stančáková, K. Schwander, Arthur A. Campbell, D. Levy, L.R. Yanek, S. Weiss, Carl D. Langefeld, N.G. Forouhi, Christopher P. Nelson, William R. Scott, Zoltán Kutalik, B L Salako, Woon‐Puay Koh, Lawrence F. Bielak, T. Alfred, T.A. Lakka, T.B. Harris, Nancy L. Pedersen, M.A. Nalls, Charumathi Sabanayagam, Chiea Chuen Khor, A. Hofman, Y.Y. Teo, T. Sofer, F.S. Collins, A. Goel, Salman M. Tajuddin, K.D. Taylor, Thomas Meitinger, C.M. Sitlani, C. Kooperberg, W.H.H. Sheu, Adesola Ogunniyi, Yun Li, Chuan Gao, Raymond Noordam, Xiuqing Guo, Stella Aslibekyan, M. Waldenberger, Sami Heikkinen, Q. Duan, Jianjun Liu, Olli Raitakari, M. Kubo, Jiang He, Jonathan Marten, A.K. Manning, Lisa de las Fuentes, Dina Vojinović, P.M. Ridker, C.B. Eaton, Nadia Amin, W. Wen, O. Polasek, T. Katsuya, Lu Yu, C. Li, B. Kühnel, José Eduardo Krieger, Renée de Mutsert, Pirjo Komulainen, Frida Renström, R. Graham Barr, M.K. Wojczynski, Mickaël Canouil, Benjamin Lehne, Bamidele O. Tayo, H.A. Koistinen, R. Dorajoo, D.E. Arking, P.A. Peyser, A. Metspalu, Ilaria Gandin, Antonietta Robino, J.M. Starr, J. Kuusisto, T.O. Kilpeläinen, E.P. Bottinger, K. Matsuda, F Takeuchi, E. Boerwinkle, Won‐Jae Lee, T.V. Varga, Sung‐Hoon Lim, Saima Afaq, T. Rankinen, Y. Liu, Chew‐Kiat Heng, Jasmin Divers, L.-P. Lyytikäinen, M.R. Irvin, Hugues Aschard, Igor Rudan, R.A. Scott, A.T. Kraja, T. Louie, L. Wang, Yi Zhou, A.V. Smith, Peter J. van der Most, D.I. Chasman, Fang‐Chi Hsu, A.R.V.R. Horimoto, Y.X. Wang, Xueling Sim, Jennifer G. Robinson, Xiaojun Chen, C.-T. Liu, Candace M. Kammerer, Marie Loh, N.D. Kerrison, Massimiliano Cocca, Wenxin Wei, Yechiel Friedlander, Hua Tang, O.H. Franco, J.M. Connell, Saskia P. Hagenaars, U. Broeckel, C. Langenberg, Blair H. Smith, Mary F. Feitosa, M.‐A. Richard, Arnab Chakravarti, Mathilde Boissel, Peter S. Braund, N.D. Palmer, C. Charles Gu, Brian E. Cade, Jim Kaufman, Hua Wang, K. Strauch, W. Zhang, Karin Leander, H.R. Warren, Barbara V. Howard, Bruna Gigante, Y. Momozawa, A.U. Jackson, Jie Yao, G. Ehret, Y.-B. Xiang, Pamela J. Schreiner, Alison R. Bentley, J.F. Chai, Yih Chung Tham, Nicola Franceschini, G. Wilson, Maris Alver, S.K. Musani, J.H. Lee, Yu Wang, H. Gao, Nana Matoba, Carsten Oliver Schmidt, R. J. Waken, Yang Jia, Ιωάννα Ντάλλα, F.P. Hartwig, Preeti Gupta, S.C. Hunt, F. Giulianini, C.E. Lewis, R. Mägi, H. Snieder
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Résumé fourni par la source
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
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