Comparison of two combined antiretroviral treatment regimens in the management of HIV in pregnancy: an observational study
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Le résumé fourni par la source
Objective Combined antiretroviral therapy (cART) in pregnancy traditionally included two nucleoside reverse transcriptase inhibitors plus 1 protease inhibitor (PI). Recently, integrase strand transfer inhibitors (INSTI) have been approved for use in pregnancy. We sought to compare the rate of undetectable VL near delivery in pregnant HIV-infected women receiving INSTI-based versus PI-based cART.Material and methods Prospective cohort study (January 2010–March 2017) of pregnant HIV-infected pregnancies receiving care in a single obstetric infectious disease clinic. Included pregnancies (total = 171; INSTI − group = 111, PI − group = 60) had at least 2 VL (before and after intervention) during pregnancy. The primary outcome was the rate of undetectable VL near delivery.Results We found comparable rates of undetectable HIV VL near delivery in pregnancies treated with INSTI-cART (74/111, 66.7%) compared to PI-cART (34/60, 56.7%; [adjusted p = .116, RR 1.26, 95% CI 0.92–2.59]). Compared to the PI-group, pregnancies in the INSTI-group showed lower median HIV VL near delivery (20 versus 50 copies/mL; adjusted p = .0454) and greater VL reduction (adjusted p = .0185). There were 3/171 (1.75%) infants diagnosed with HIV, 1 in the INSTI-group and 2 in the PI-group (p = .5635, RR 0.51, 95% CI 0.10–2.53).Conclusion Pregnant HIV-infected women receiving either INSTI- or PI-based cART achieved comparable rates of undetectable HIV VL near delivery with similar perinatal transmission.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comparison of two combined antiretroviral treatment regimens in the management of HIV in pregnancy: an observational study
- Date Crossref
- 24/11/2019
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Tennessee Health Science Center Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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St. Jude Children's Research Hospital Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Inova Health System pays non établi dans la noticeÉtablissement de santé
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Indian River State College pays non établi dans la noticeUniversité ou école supérieure
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Department of Obstetrics and Gynecology pays non établi dans la noticeInstitution
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Florida Woman Care of Indian River County pays non établi dans la noticeInstitution
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Perinatal Associates of Northern Virginia pays non établi dans la noticeInstitution
Department of Obstetrics and Gynecology — University of Tennessee Health Science Center, Department of Infectious Diseases — St. Jude Children's Research Hospital et Inova Health System, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.