Accès ouvert déclaré
2019
article
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
Vivek Patel, Evan L. Busch, Tara M. Friebel, Angel M. Cronin, Goska Leslie, Lesley McGuffog, Julian Adlard, Simona Agata, Bjarni Agnar Agnarsson, Munaza Ahmed, Kristiina Aittomäki, Elisa Alducci, Irene Louise Andrulis, Aðalgeir Arason, Norbert Arnold, Grazia Artioli, Brita Wasteson Arver, Bernd Auber, Jacopo Azzollini, Judith Balmañà, Rosa Bjork Barkardottir, Daniel R. Barnes, Alicia Barroso, Daniel Barrowdale, Muriel Belotti, Javier Benı́tez, Birgitte Møllegaard Bertelsen, Marinus J. Blok, I. Bodrogi, Valérie Bonadona, Bernardo Bonanni, Davide Bondavalli, Susanne E. Boonen, Julika Borde, Åke Borg, Angela R. Bradbury, Angela Brady, Carole Brewer, Joan Brunet, Bruno Buecher, Saundra S. Buys, Santiago Cabezas-Camarero, Trinidad Caldés, Almuth Caliebe, Maria Adelaide Caligo, Mariarosaria Calvello, Ian Campbell, Ileana Wanda Carnevali, Estela Carrasco, Tsun Leung Chan, Annie Tsz-Wai Chu, Wendy K. Chung, Kathleen Claes, GEMO Study Collaborators, EMBRACE Collaborators, Jackie A Cook, Laura Cortesi, Fergus J. Couch, Mary B. Daly, Giuseppe Damante, Esther Darder, Rosemarie Davidson, Miguel de la Hoya, Lara Della Puppa, Joe Dennis, Orland Dı́ez, Yuan Chun Ding, Nina Caroline Ditsch, Susan M. Domchek, Alan Donaldson, Bernd Dworniczak, Douglas F. Easton, Rosalind A. Eeles, Hans Ehrencrona, Bent Ejlertsen, Christoph Engel, D. Gareth Evans, Laurence Faivre, Ulrike Faust, Lídia Feliubadaló, Lenka Foretová, Florentia Fostira, George Fountzilas, Debra Frost, Vanesa García‐Barberán, Pilar Garré, Marion Gauthier‐Villars, Lajos Géczi, Andrea Gehrig, Anne‐Marie Gerdes, Paul Gesta, Giuseppe Giannini, Gord Glendon, Andrew K. Godwin, David E. Goldgar, Mark H. Greene, Angelica M. Gutierrez‐Barrera, Eric Hahnen, Ute Hamann, Jan Hauke, Frans B.L. Hogervorst, Ellen Honisch, John Llewelyn Hopper, Peter J. Hulick, kConFab Investigators, Hebon Investigators, Louise Izatt, Agnes Jager, Paul Andrew James, Ramūnas Janavičius, Uffe Birk Jensen, Thomas D. Jensen, Oskar T. Johannsson, Esther M. John, Joseph Vijai, Eunyoung Kang, Karin Kast, Johanna I. Kiiski, Sung-Won Kim, Zisun Kim, Kwang‐Pil Ko, Irene Konstantopoulou, Gero Kramer, Lotte Krogh, Torben A. Kruse, Ava Kwong, Mirjam Larsen, Christine Lasset, Charlotte Kvist Lautrup, Conxi Lázaro, Jihyoun Lee, Jong Won Lee, Min Hyuk Lee, Johannes R. Lemke, Fabienne Lesueur, Annelie Liljegren, Annika Lindblom, Patricia Llovet, Adrià López‐Fernández, Irene López‐Perolio, Víctor Lorca, Jennifer T. Loud, Edmond S.K. Ma, Siranoush Manoukian, Véronique Mari, Lynn M. Martin, Laura Matricardi, Noura Mebirouk, Veronica Medici, Hanne E.J. Meijers-Heijboer, Alfons Meindl, Arjen R. Mensenkamp, Clare M. Miller, Denise Molina Gomes, Marco Montagna, Thea M. Mooij, Lidia Moserle, Emmanuelle Mouret‐Fourme, Anna Marie Mulligan, Katherine L. Nathanson, Marie Navrátilová, Heli A. Nevanlinna, Dieter Niederacher, Finn C. Nielsen, Liene Ņikitina-Zaķe, Kenneth Offit, Edith Oláh, Olufunmilayo Ibironke Olopade, Kai-Ren Ong, Ana Osório, Claus‐Eric Ott, Domenico Palli, Sue K. Park, Michael T. Parsons, Inge Søkilde Pedersen, Bernard Peissel, Ana Peixoto, Pedro Pérez‐Segura, Paolo Peterlongo, Annabeth Høgh Petersen, Mary E. Porteous, Miguel Ángel Pujana, Paolo Radice, Juliane Ramser, Johanna Rantala, Muhammad Usman Rashid, Kerstin Rhiem, Piera Rizzolo, Mark E. Robson, Matti A. Rookus, Caroline Maria Rossing, Kathryn J. Ruddy, Catarina Santos, Claire Saule, Rosa Scarpitta, Rita Katharina Schmutzler, Hélène Schuster, Leigha Senter, Caroline Seynaeve, Payal Deepak Shah, Priyanka Sharma, Vivian Yvonne Shin, Valentina Silvestri, Jacques Simard, Christian Fridolin Singer, Anne‐Bine Skytte, Katie M.G. Snape, Angela Rosaria Solano, Penny Soucy, Melissa C. Southey, Amanda B. Spurdle, Linda Roslyn Steele, Doris Steinemann, Dominique Stoppa‐Lyonnet, Agostina Stradella, Lone Sunde, Christian Sutter, Yen Y. Tan, Manuel Rodrigues Teixeira, Soo‐Hwang Teo, Mads Thomassen, Maria Grazia Tibiletti, Marc D. Tischkowitz, Silvia Tognazzo, Amanda Ewart Toland, Stefania Tommasi, Diana Milena Torres, Angela Toss, Alison H. Trainer, Nadine Tung, Christi J. van Asperen, Frederieke H. van der Baan, Lizet E. van der Kolk, Rob B. van der Luijt, Liselotte P. van Hest, Liliana Varesco, Raymonda Varon-Mateeva, Alessandra Viel, Jeroen Vierstraete, Roberta Villa, Anna von Wachenfeldt, Philipp Wagner, Shan Wang‐Gohrke, Barbara Wappenschmidt, Jeffrey N. Weitzel, Greet Wieme, Siddhartha Yadav, Drakoulis Yannoukakos, Sook‐Yee Yoon, Cristina Zanzottera, Kristin K. Zorn, Anthony Victor D'Amico, Matthew L. Freedman, Mark M. Pomerantz, Georgia Chenevix‐Trench, Antonis C. Antoniou, Susan L. Neuhausen, Laura Ottini, Henriette Roed Nielsen, Timothy Richard Rebbeck
53Citations signalées, ce qui n’est pas une note de qualité
181Institutions déclarées
29Pays d’affiliation déclarés
Rattachement africain : us, gb, it, is, fi, ca, de, se, es, fr, dk, nl, hu, au, hk, be, pl, cz, gr, lt, kr, at, lv, Éthiopie, pt, pk, ar, my, co.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3′ region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63–5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71–4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12–11.54; P = 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. Significance: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Association of Genomic Domains in <i>BRCA1</i> and <i>BRCA2</i> with Prostate Cancer Risk and Aggressiveness
- Date Crossref
- 01/02/2020
- Éditeur
- American Association for Cancer Research (AACR)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
BRCA gene mutations in cancerPARP inhibition in cancer therapyDNA Repair Mechanisms