Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality
Rattachement africain : gb, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Viral respiratory infections (VRIs) contribute to the morbidity and transplant-related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and strategies to prevent and treat VRIs are warranted. We monitored VRIs before and after transplant in children undergoing allogeneic HSCT with nasopharyngeal aspirates (NPA) and assessed the impact on clinical outcome. Between 2007 and 2017, 585 children underwent 620 allogeneic HSCT procedures. Out of 75 patients with a positive NPA screen (12%), transplant was delayed in 25 cases (33%), while 53 children started conditioning with a VRI. Patients undergoing HSCT with a positive NPA screen had a significantly lower overall survival (54% vs. 79%) and increased TRM (26% vs. 7%) compared to patients with a negative NPA. Patients with a positive NPA who delayed transplant and cleared the virus before conditioning had improved overall survival (90%) and lower TRM (5%). Pre-HSCT positive NPA was the only significant risk factor for progression to a lower respiratory tract infection and was a major risk factor for TRM. Transplant delay, whenever feasible, in case of a positive NPA screen for VRIs can positively impact on survival of children undergoing HSCT.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality
- Date Crossref
- 30/09/2019
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Great Ormond Street Hospital for Children NHS Foundation Trust Bone Marrow Transplantation Department pays non établi dans la noticeÉtablissement de santé
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University of Milano-Bicocca Department of Paediatrics pays non établi dans la noticeUniversité ou école supérieure
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University College London Division of Infection and Immunity pays non établi dans la noticeUniversité ou école supérieure
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Department of Paediatrics University of Milano‐Bicocca San Gerardo Hospital/Fondazione MBBM Monza Italy pays non établi dans la noticeUniversité ou école supérieure
Bone Marrow Transplantation Department — Great Ormond Street Hospital for Children NHS Foundation Trust, Department of Paediatrics — University of Milano-Bicocca et Division of Infection and Immunity — University College London, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.