Haematological Alterations Induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Male Wistar albino Rats

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The present study was aimed to know the haematological alteration due to individual toxicities of cadmium, chlorpyrifos and their combination in albino wistar rats. The experiment was carried out for 28 days. Group 1 - Control. Group 2 - Cadmium chloride (Cd) @ 22.5mg/ kg b.wt /per oral / day. Group 3 - Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. Group 4 - Cadmium chloride (Cd) @22.5 mg + Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. The weekly body weight gains were significantly (P < 0.05) decreased in groups 4, 3 and 2 when compare with control group. Haematological observations revealed a significant (P < 0.05) decrease in overall means of TEC, Hb, PCV in except TLC in groups 4, 2 and 3 when compare with control group. TLC values were increased 4, 2 and 3. These results revealed that combined toxicity of cadmium and chlorpyrifos is significant than exposure of individual components which resulted in alterations in haematological parameters.

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