Increased liver echogenicity and liver enzymes are associated with extreme obesity, adolescent age and male gender: analysis from the German/Austrian/Swiss obesity registry APV
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Le résumé fourni par la source
BACKGROUND: Childhood obesity is often associated with non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in pediatrics. METHODS: , 50% boys) with overweight (BMI >90th percentile), obesity (BMI >97th percentile) or extreme obesity (BMI > 99.5th percentile) and obesity related comorbidities, especially NAFLD from 26 centers of Germany, Austria and Switzerland. Liver enzymes aspartate aminotransferase (AST), alanine-aminotransferase (ALT) and gamma glutamyltransferase (gammaGT) were evaluated using 2 cut-off values a) > 25 U/L and b) > 50 U/L. Multiple logistic regression models were used for statistical analysis. RESULTS: In total, 44% of the patients showed increased liver echogenicity. Liver enzymes > 25 U/L were present in 64% and > 50 U/L in 17%. Increased liver echogenicity was associated with elevated liver enzymes (> 25 U/L: odds ratio (OR) = 1.4, 95% CI: 1.1-1.9, P < 0.02; > 50 U/L: OR = 3.5, 95% CI: 2.4-5.1, P < 0.0001). Extreme obesity, adolescence and male gender were associated with increased liver echogenicity (extreme obesity vs overweight OR = 3.5, 95% CI: 1.9-6.1, P < 0.0001; age > 14 years vs age < 9 years OR = 2.2, 95% CI: 1.4-3.5, P < 0.001; boys vs girls OR = 1.6, 95% CI: 1.2-2.0, P < 0.001) and elevated liver enzymes (extreme obesity vs overweight > 25 U/L: OR = 4.1, 95% CI: 2.4-6.9, P < 0.0001; > 50 U/L: OR = 18.5, 95% CI: 2.5-135, P < 0.0001; age > 14 years vs age < 9 years > 50 U/L: OR = 1.9, 95% CI: 1.0-3.7, P > 0.05; boys vs girls > 25 U/L: OR = 3.1, 95% CI: 2.4-4.1, P < 0.0001; > 50 U/L: OR = 2.1, 95% CI: 1.5-2.9, P < 0.0001). Impaired glucose metabolism showed a significant correlation with elevated liver enzymes > 50 U/L (OR = 4.4, 95% CI: 1.6-11.8, P < 0.005). Arterial hypertension seemed to occur in patients with elevated liver enzymes > 25 U/L (OR 1.6, 95% CI: 1.2-2.0, P < 0.005). CONCLUSIONS: NAFLD is strongly related to extreme obesity in male adolescents. Moreover impaired glucose tolerance was observed in patients with elevated liver enzymes > 50 U/L, but arterial hypertension was only present in patients with moderately elevated liver enzymes > 25 U/L.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Increased liver echogenicity and liver enzymes are associated with extreme obesity, adolescent age and male gender: analysis from the German/Austrian/Swiss obesity registry APV
- Date Crossref
- 12/09/2019
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Medical University of Vienna Department of Pediatrics and Adolescent Medicine pays non établi dans la noticeUniversité ou école supérieure
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Fraunhofer Institute for Technological Trend Analysis pays non établi dans la noticeStructure de recherche
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Universität Ulm pays non établi dans la noticeUniversité ou école supérieure
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Zimmer Biomet (Germany) pays non établi dans la noticeEntreprise
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Specialist Hospital for Pediatric Rehabilitation pays non établi dans la noticeÉtablissement de santé
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Children`s Hospital Prinzessin Margaret pays non établi dans la noticeÉtablissement de santé
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High Mountains Clinic Mittelberg pays non établi dans la noticeÉtablissement de santé
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Obesity Rehabilitation Center Insula pays non établi dans la noticeInstitution
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Department of Paediatrics and Adolescent Medicine pays non établi dans la noticeInstitution
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HELIOS Hospital of the district Gotha Department of Paediatrics pays non établi dans la noticeÉtablissement de santé
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Euskirchen Community Paediatric Clinic pays non établi dans la noticeÉtablissement de santé
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University of Ulm Institute of Epidemiology and Medical Biometry pays non établi dans la noticeUniversité ou école supérieure
Department of Pediatrics and Adolescent Medicine — Medical University of Vienna, Fraunhofer Institute for Technological Trend Analysis et Universität Ulm, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.