Abstract 17024: Venous Thromboembolism (VTE) Mortality Trends in the Pediatric Population: A Retrospective Analysis of the National Inpatient Sample (NIS) Database

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Background: Venous thromboembolism (VTE) is one of the leading preventable cardiovascular diseases and responsible for approximately 300,000 deaths per year in the US. There is paucity of data regarding mortality secondary to VTE in the pediatric population. Aim: To determine the mortality trends due to VTE in hospitalized patients among the pediatric population. Methods: We perform a retrospective analysis of the National Inpatient Sample (NIS) database. The cohort group consisted in hospitalized patients under the age of 18 with a diagnosis of VTE. We used the ICD-9 coding system to identify the diagnosis of VTE. Patients were included only if VTE was considered within the first four discharge diagnoses. We used simple logistic regression to calculate trends. All statistical analyses were performed in SPSS software version 22. Chicago, Illinois. Results: A total of 4961 (not weighted) patients (female: 2567 (51.7%), mean age: 12.19 (SD=5.7), neonate to infant: 553 (11.1%), toddler: 173 (3.5%), preschool: 197 (4%), school: 751 (15.1%), adolescent: 3287 (66.3%)) were included. The prevalence of VTE by age group showed a J-shaped curve and was more commonly seen among adolescents. Fig. 1. A total of 93 patients died (1.9%). Pulmonary embolism (PE) occurred in 1835 patients (36.5%). Among patients with PE, 4.4% died compared to 0.4% with non-PE (OR: 10.9 95% CI 5.8-18.1, p: <0.001). No trend in mortality was observed over a period of 10 years p: 0.19. Fig. 2. Conclusion: The inpatient mortality rate secondary to VTE among pediatric patients is low. Patients with PE have a 11-fold increased mortality likelihood compared to non-PE patients. No mortality trends were observed.

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