Abstract P070: Dyslipidemic Adolescent and Adult African Americans Have Similar Cardio-Metabolic Risk

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Background: African Americans (AA) are at increased risk for developing diabetes mellitus. However, they are known to have lower triglycerides (TG) and higher high density lipoprotein-cholesterol (HDL-C) than other ethnic groups. Among AA, it is thought that adolescents are at lower cardiovascular risk and have lower levels of metabolic co-variants than adults, but there are no studies directly comparing adolescents and adults. Objective: To compare AA adolescents to adults with regard to the relationships of adiposity-related lipid risk markers (TG/HDL ratio and non HDL-C) with body mass index (BMI), waist circumference (WC), homeostasis model of insulin resistance (HOMA), and serum high sensitivity C-Reactive Protein (hsCRP). Methods: Healthy AAs (283 adolescents, 484 adults) were recruited from the same urban community. To create TG/HDL strata, adult tertiles were established. Non HDL-C strata were based on ATP III/NHLBI expert guidelines. Adolescents and adults in the low, middle and high strata were compared with regard to BMI, WC, HOMA, and hsCRP. Results: As both TG/HDL ratio and non HDL-C strata increased, BMI, WC, HOMA, and hsCRP increased in both adolescents and adults (Tables). Among 16% (44/283) of adolescents and 33% (161/484) of adults having a TG/HDL ratio above 2.028 (High group), BMI, WC, and hsCRP were similar in both age groups (Table 1). In 8% (22/283) of adolescents and 12% (60/484) of adults having an elevated non HDL-C (HIgh group), BMI, WC, and hsCRP were also similar (Table 2). HOMA was higher in adolescents, but after accounting for this age difference, was significantly associated with the high TG/HDL ratio and non HDL-C strata. Slopes of these relationships were steeper in adolescents than adults, therefore adolescents in the lower lipid strata had lower BMI, WC, HOMA, and hsCRP. Conclusions: Elevated TG/HDL ratio and non HDL-C are associated with similar levels of metabolic risk in adolescent and adult AAs. The relationship between HOMA and dyslipidemia is stronger in adolescent versus adult AAs.

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