MON-200 EFFECT OF MATERNAL HYPOXIA ON GLOMERULAR AND PODOCYTE ENDOWMENT IN MALE AND FEMALE OFFSPRING

Résumé fourni par la source

Impaired oxygen supply to the fetus is a common complication of pregnancy which is associated with reduced blood flow to the fetal kidney and reduced birth weight. The kidney is highly susceptible to an adverse intrauterine environment and a deficiency in the number of nephrons is associated with increased risk of hypertension and renal disease. Glomerular podocytes have a limited capacity to replicate under normal circumstances in mature animals, and the depletion of these cells is correlated with development of glomerulosclerosis and decreased renal function.

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