Hemoglobin CC and SC Red Cells

Le résumé fourni par la source

Hemoglobin C was first described in the heterozygous state by H. A. Itano and O. V. Neel in 1950 and the first homozygous case was reported by T. H. Spaet et al. in 1953. Homozygous hemoglobin C containing cells are noted for their bizzare morphology: in wet slides microcytic and hyperchromic cells are seen, and in dried slides target cells, microspherocytes, and cells with crystalline inclusions are found. High mean corpuscular hemoglobin concentration and low intracellular water content have been noted as a characteristic of HbC containing cells by a number of workers. Electrophoresis on cellulose acetate at pH 8.6 readily demonstrates the presence of hemoglobin S and C. Although the presence of homozygous hemoglobin C is often only moderately symptomatic, some aspects of hemoglobin SC disease approach the severity of sickle cell anemia. Smears of blood from patients with SC disease show numerous target cells.

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