Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study
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Le résumé fourni par la source
BACKGROUND AND OBJECTIVE: Symptoms negatively impact the quality of life and long-term prognosis of patients with chronic obstructive pulmonary disease (COPD). Little is known about the relationship linking airway inflammation and symptoms in stable COPD. In this study, we evaluated whether respiratory symptoms in COPD are related to sputum inflammatory cellular profile and whether symptom changes are associated with changes in airway inflammation. METHODS: A total of 40 patients with stable COPD with moderate-to-severe airflow obstruction were enrolled. Patients were visited weekly over 4 weeks. At each visit, patients underwent clinical assessments, lung function tests and sputum induction. Patients recorded daily dyspnoea, sputum and cough scores. RESULTS: The changes between two consecutive visits in the percent of sputum neutrophils and eosinophils were related to the changes in the cough (P < 0.001; r = 0.63) and dyspnoea scores (P < 0.001; r = 0.58) of the prior week. Furthermore, using regression analyses, we were able to demonstrate that changes in the cough score were specifically associated to the change in neutrophils, while changes in the dyspnoea score and use of rescue medications were associated with changes in eosinophils numbers. CONCLUSION: Our study showed an association between symptoms and the sputum inflammatory profile. In particular, changes in symptoms (cough and dyspnoea) were correlated with changes in the specific sputum inflammatory cell components of airway inflammation (neutrophils and eosinophils, respectively), providing novel information on the mechanisms of disease manifestation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study
- Date Crossref
- 28/06/2019
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Ferrara Research Centre on Asthma and COPD pays non établi dans la noticeUniversité ou école supérieure
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University of Padua pays non établi dans la noticeUniversité ou école supérieure
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University of Verona pays non établi dans la noticeUniversité ou école supérieure
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University of Insubria pays non établi dans la noticeUniversité ou école supérieure
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Department of Cardiac Thoracic Vascular Sciences and Public Health University of Padova Padova Italy pays non établi dans la noticeUniversité ou école supérieure
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Cros NT Verona Italy pays non établi dans la noticeInstitution
Research Centre on Asthma and COPD — University of Ferrara, University of Padua et University of Verona, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.