Epimerization-Free Amidation of Protected Peptide Acids

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All articles of this category An investigation was performed on the formation of amides and substituted amides of N -(9-fluorenylmethoxycarbonyl) di-, tri-, tetra-, penta- and hexapeptide acids with the crystalline ammonium, methylammonium, ethylammonium and benzylammonium salts of N -hydroxysuccinimide, and also on the rates of racemization in the amidation process. The precise stereochemical purities of the products were measured by conventional HPLC, using pre-column derivatization with Marfey’s reagent, and proved to be on average 98%. amidation - chirality - optical purity - peptide - racemization

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