Comparative analgesic efficacy and tolerability of celecoxib and tramadol on postoperative pain after mandibular third molar extraction: A double blind randomized controlled trial
Rattachement africain : Nigéria. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The choice of an efficacious and well-tolerated analgesic for the control of postoperative pain after third molar surgical extraction remains a challenge. AIM: The aim of this study was to compare analgesic efficacy and tolerability of celecoxib and tramadol following mandibular third molar extraction. MATERIALS AND METHODS: This was a prospective randomized, double blind controlled trial. Ninety patients were randomly assigned equally to either celecoxib or tramadol. Appropriate doses of the assigned drugs were administered orally immediately after the surgical extraction and patients recorded the pain intensity felt before the extraction, immediately after extraction, at 4 h, 8 h, 16 h, 24 h, and 48 h after the extraction using the visual analogue scale (VAS). Adverse effects of the medications were also recorded. RESULTS: Four of the patients dropped out of the study. Fifty five percent of patients in tramadol group experienced adverse effects but none in celecoxib group. The median VAS score of the celecoxib group was lower than tramadol group throughout the postoperative period and there was statistically significant difference in the median VAS score between the two groups 4 hours after drug administration (P = 0.001). CONCLUSION: In our study, celecoxib was more efficacious and better tolerated than tramadol for the management of pain after surgical extraction of mandibular third molar.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comparative analgesic efficacy and tolerability of celecoxib and tramadol on postoperative pain after mandibular third molar extraction: A double blind randomized controlled trial
- Date Crossref
- 01/01/2019
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Afe Babalola University Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Nigeria Teaching Hospital Department of Oral and Maxillofacial Surgery Enugu, Nigéria (code pays fourni par la source)Établissement de santé
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Obafemi Awolowo University Department Oral and Maxillofacial Surgery Ile-Ife, Nigéria (code pays fourni par la source)Université ou école supérieure
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Faculty of Clinical Sciences Department of Dental and Maxillofacial Surgery Ado-Ekiti, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
Afe Babalola University (Nigéria), Department of Oral and Maxillofacial Surgery — University of Nigeria Teaching Hospital (Enugu, Nigéria) et Department Oral and Maxillofacial Surgery — Obafemi Awolowo University (Ile-Ife, Nigéria), avec 1 autre affiliation. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.