230Anderson-Fabry disease: beyond what "eyes can see"

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Introduction: cardiac magnetic resonance (CMR) plays a major role in the assessment of cardiac involvement in Anderson-Fabry (ADF) disease and in subsequent therapeutic decisions. CMR feature tracking (CMR-FT) allows a fast and accurate assessment of strain analysis avoiding the need of additional sequences. Purpose: assess the utility of CMR-FT in the evaluation of the cardiac involvement by AFD. Methods: included seventy-six consecutive genetically proven ADF patients, from a single reference center, and thirty-nine controls (matching for age and sex). The participants provided written informed consent. CMR-FT was performed by a level III operator using a dedicated software. Results: Globally, AFD patients had worse strain results (table 1). But even patients both without left ventricle hypertrophy and without presence of late gadolinium enhancement (52.6%) had worse results when comparing to controls (values not presented). In this particular sub-group, parameters with higher area under the curve (AUC) were longitudinal strain rate (p < 0.001; AUC 0,84; cut-off value of -0.93%, sensibility 85%, specificity 70%) and circumferential strain rate (p < 0.001; AUC 0.88; cut-off -1.00%, sensibility 85%, specificity 70%). Conclusion: even in very initial stages, strain is already affected in AFD. CMR-FT can provide additional data without lengthening a CMR study. table 1: main CMR results LV - left ventricle RV- right ventricle 2D - two-dimensional 3D - three-dimensional

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