A MULTICENTER STUDY ON THE PREVALENCE OF EOSINOPHILIC ESOPHAGITIS IN THE CENTRAL REGION OF THE RUSSIAN FEDERATION AMONG ADULTS UNDERGOING UPPER GASTROINTESTINAL ENDOSCOPY

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Aims: The aim of this study was to evaluate the prevalence of eosinophilic esophagitis (EoE) in the central region of the Russian Federation among adult patients undergoing upper gastrointestinal (UGI) due to upper gastrointestinal symptoms. Methods: This study was conducted in 5 endoscopy departments in the central region of the Russian Federation (4 in Moscow, 1 in Yaroslavl). During a 12 month period (from October 2017 to October 2018) 23740 adult patients (aged 18 – 80 years) were evaluated using UGI endoscopy due to symptoms (heartburn, dysphagia, food impaction, acid regurgitation, chest pain, epigastric pain, nausea, vomiting). In patients with endoscopic findings of EoE (edema, rings, exudates, furrows, and strictures) 8 biopsies were obtained from the proximal and distal esophagus to quantify the maximum eosinophil count per high-power field (eos/hpf; hpf = 0.24 mm) by a gastrointestinal pathologist. EoE was defined by ≥15 eosinophils/high-power field. Results: UGI endoscopy revealed typical endoscopic features of EoE in 47 patients. Esophageal biopsy confirmed EoE in 18 (0.076%) cases (male – 77,7%, female – 22,3%). The average age was 37.25 years (rank 21 – 67), 88.8% of patients were under 45 years of age. Individuals with EoE suffered from dysphagia (61.1%), heartburn (50%), food impaction (33.3%), and nursea (38.8%). 83.3% of EoE patients had a past history of gastroesophageal reflux disease, 27.7% suffered from allergic rhinitis, 33.3% had atopic dermatitis, 11.1% -asthma. 1 patient had a family history of EoE (his sibling and mother also suffered from dysphagia due to EoE). Conclusions: The prevalence of EoE among adult patients undergoing upper endoscopy in the Russian Federation is 0.076% (1 case for 1319 UGI endoscopies). The characteristic findings of EoE patients included predominantly male gender, age under 45 years and history of atopic diseases.

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