Pub medic Artificial blood

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Is it worth all the hype? Thomas Mac Mahon and J Adrian Copplestone find out In cases of massive haemorrhage, patients die rapidly from hypovolaemia and lack of tissue oxygenation. Management consists of controlling the leak, restoring blood volume, and improving oxygenation, but is sometimes difficult if the patient is lying on a battlefield or is trapped at the scene of a road traffic accident where blood transfusions are not readily available. What if the paramedics at the scene could use a blood substitute instead, saving time and lives? Current trials are investigating whether artificial blood can live up to this exciting promise. Spot the agglutination Blood has a variety of functions in human physiology, including gas, nutrient, and hormone transport; waste removal; and delivery of immune and coagulation system components. Although eventually a synthetic product may be developed that can mimic all of these roles, current research into artificial blood is focused on the critical areas of oxygen delivery and blood volume replacement. As such, scientists are trying to come up with a liquid that can deliver oxygen as efficiently as erythrocytes can, rather than making erythrocytes themselves. If successful, artificial blood would have obvious advantages over donated blood1:

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