Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding “Normal” Inflammation to Inform Future Screening
Rattachement africain : us, mx. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: This study aimed to describe characteristics of cervicovaginal cytokines obtained during pregnancy from women who subsequently delivered at term. STUDY DESIGN: We used repeated measures of 20 cervicovaginal cytokines, collected on average on a monthly basis, from the second to the ninth month of gestation among 181 term pregnancies in the Mexico City Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses cohort (2009-2014). Cytokines were quantified using multiplex assay. RESULTS: Cytokine distributions differed more between than within cytokines. Across trimesters, cytokines interleukin (IL)-1Ra, IL-1α, and IL-8 consistently had high concentrations compared with other measured cytokines. Cytokine intraclass correlation coefficients ranged from 0.41 to 0.82. Spearman's correlation coefficients among cytokine pairs varied but correlation directions were stable; 95.3% of the 190 correlation pairs remained either negative or positive across trimesters. Mean longitudinal patterns of log-transformed cytokines from Tobit regression varied across but less within cytokines. CONCLUSION: Although mean concentrations of cervicovaginal cytokines among term pregnancies were high, they were largely stable over time. The high cytokine concentrations corroborate that pregnancy is associated with an active inflammatory state. These characterizations may serve as a baseline for comparison to other obstetric outcomes, which may be helpful in understanding deviations from normal gestational inflammation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding “Normal” Inflammation to Inform Future Screening
- Date Crossref
- 12/04/2019
- Éditeur
- Georg Thieme Verlag KG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Michigan Department of Environmental Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Genomic Medicine pays non établi dans la noticeOrganisme public
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Universidad Nacional Autónoma de México Unidad de Vinculación Científica de la Facultad de Medicina pays non établi dans la noticeUniversité ou école supérieure
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Institute for Social Research pays non établi dans la noticeInstitution
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Sub-comité Académico de Ginecología y Obstetricia pays non établi dans la noticeInstitution
Department of Environmental Health Sciences — University of Michigan, National Institute of Genomic Medicine et Unidad de Vinculación Científica de la Facultad de Medicina — Universidad Nacional Autónoma de México, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.