Risk factors for complications of Peripherally Catheters Central Insertion (PICC) of prolonged use in patients with solid tumors treated with chemotherapy.

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e20731 Background: PICC is offered to oncologic patients as a more comfortable and usefulness alternative for chemotherapy infusion. With the aim of analyze the rate of catheter-related events, potential risk factors for complications and the feasibility of using for long time we report the experience in our center. Methods: prospective study of patients with solid tumors and PICC inserted (Power PICC, single lumen 5 French, Bard Access Systems, Salt Lake City. UT) at Valme Hospital from January 1,2013 to December 31, 2014. The PICC were placed in the basilic vein ultrasound and RX guided by an expert physician.Patients were trained in catheter care by experienced staff.Clinical information and risk factors include: gender, stage, bevacizumab, antiagregant , erythropoiesis-stimulating agents and/or corticosteroid treatment, comorbidity, type of cancer, neutrophenic risk of chemotherapy, hospitalization, invasive procedure, time to PICC removement and event related to catheter. Results: We study 151 consecutive patients (mean age 57; range 23-85). The most common diagnoses were colorectal (CCR) (45%) and breast cancer (27.8%). 62.3% of them with advanced disease.PICCs were in place for 25667 catheter-days (median time 154 days; range 2 to 630 days). 29 PICCs (19,2%) were removed early because of any complication for a rate of 1.1 per 1000 catheter days.The rate of infection was 0, 27 per 1000 catheter days and the rate of thrombosis was 0,46 per 1000 catheter days.The mean duration of catheter was lower in < 65 years (p = 0,034; IC 95% -79,2 to -3,1) and longer in metastasis disease and CCR (p = 0,005 and p = 0,001).We found that infection events were more frequent in the first 3 months ( 71%, OR 8.75; p = 0,001; 95% CI 1.6 to 47.2). Patients with corticosteroid treatment had higher rate of infections (OR 5,7; p = 0,03; 95% CI 1.2 to 27) No differences have been seen in the other analyzed factors such as antiplatelet or bevacizumab treatment Conclusions: Prolonged use of PICC is safe in patients with cancer with a low incidence of complications. The use of corticosteroids is associated with a higher rate of infections, especially in the first three months of the PICC Insertion.

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