Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis
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Le résumé fourni par la source
BACKGROUND: Increasing evidence indicates that the gut microbiota contributes to the occurrence and development of metabolic diseases. However, little is known about the effects of commonly used antidiabetic agents on the gut microbiota. In this study, we investigated the roles of dipeptidyl peptidase-4 inhibitors (DPP-4i) and α-glucosidase inhibitor in modulating the gut microbiota. METHODS: 16S-rDNA sequencing was performed to analyse the effects of DPP-4i and acarbose on the gut microbiota in mice fed a high-fat diet (HFD). Fecal microbiota transplantation (FMT) from type 2 diabetes patients to germ-free mice was performed to investigate the contribution of the altered microbiome to antidiabetic effects of the drugs. Fecal metabolomics was also analysed by untargeted and targeted GC-MS systems. FINDINGS: Although DPP-4i and α-glucosidase inhibitor both altered the gut microbial composition, only the microbiome modulation of DPP-4i contributed to its hypoglycemic effect. Specifically, the changes of 68.6% genera induced by HFD were rescued by DPP-4i. FMT showed that the DPP-4i-altered microbiome improved glucose tolerance in colonized mice, while acarbose did not. Moreover, DPP-4i increased the abundance of Bacteroidetes, and also promoted a functional shift in the gut microbiome, especially increasing the production of succinate. INTERPRETATION: Our findings demonstrate an important effect of DPP-4i on the gut microbiota, revealing a new hypoglycemic mechanism and an additional benefit of it. Furthermore, modulating the microbial composition, and the functional shift arising from changes in the microbiome, might be a potential strategy for improving glucose homeostasis. FUND: This work was supported by grants from the National Natural Science Foundation of China (No. 81700757, No. 81471039, No. 81700714 and No. 81770434), the National Key R&D Program of China (No. 2017YFC1309602, No. 2016YFC1101100, No. 2017YFD0500503 and No. 2017YFD0501001), and the Natural Science Foundation of Chongqing (No. cstc2014jcyjjq10006, No. cstc2016jcyjA0093 and No. cstc2016jcyjA0518).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis
- Date Crossref
- 01/06/2019
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Army Medical University pays non établi dans la noticeUniversité ou école supérieure
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Xinqiao Hospital pays non établi dans la noticeÉtablissement de santé
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Guiyang Medical University pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Guizhou Medical University Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Texas A&M University Department of Nutrition and Food Science pays non établi dans la noticeUniversité ou école supérieure
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Dalian Medical University pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital of Chongqing Medical University Department of Endocrinology pays non établi dans la noticeÉtablissement de santé
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Chongqing Medical University pays non établi dans la noticeUniversité ou école supérieure
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Daping Hospital pays non établi dans la noticeÉtablissement de santé
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Third Military Medical University Department of Endocrinology pays non établi dans la noticeUniversité ou école supérieure
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College of Basic Medical Sciences Department of Laboratory Animal Science pays non établi dans la noticeUniversité ou école supérieure
Army Medical University, Xinqiao Hospital et Guiyang Medical University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.