Neuroimaging evolution of ischemia in men and women: an observational study
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Objective We present an exploratory study for identification of sex differences in imaging biomarkers that could further refine selection of patients for acute reperfusion therapy and trials based on sex and imaging targets. Methods The Lesion Evolution in Stroke and Ischemia On Neuroimaging (LESION) study included consecutive acute stroke patients who underwent MRI within 24 h of time from last known well and prior to therapy. Those demonstrating a potential therapeutic target on imaging were identified by presence of: (1) arterial occlusion on angiography, (2) focal ischemic region on perfusion maps, or (3) a mismatch of perfusion versus diffusion imaging lesion size. The prevalence of imaging targets within clinically relevant time intervals was calculated for each patient and examined. The relationship of time from stroke onset to probability of detection of imaging targets was evaluated. Results Of 7007 patients screened, of which 86.7% were scanned with MRI, 1092 patients (477/615 men/women) were included in LESION. The probability of imaging target detection was significantly different between men and women, with women more likely to present with all assessed imaging targets, odds ratios between 1.36 and 1.59, P < 0.02, adjusted for NIHSS, age, and time from last known well to MRI scan. This trend held for the entire 24‐h studied. Interpretation Women present more often with treatable ischemic stroke than men. The greater probability of potentially viable and/or treatable imaging targets in women at all time points suggests that tissue injury is slower to evolve in women.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neuroimaging evolution of ischemia in men and women: an observational study
- Date Crossref
- 21/02/2019
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
The University of Texas at Austin pays non établi dans la noticeUniversité ou école supérieure
-
National Institutes of Health pays non établi dans la noticeOrganisme public
-
National Institute of Neurological Disorders and Stroke pays non établi dans la noticeStructure de recherche
-
The University of Texas Health Science Center Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
-
The University of Texas Health Science Center at Houston pays non établi dans la noticeUniversité ou école supérieure
-
The University of Texas Southwestern Medical Center pays non établi dans la noticeÉtablissement de santé
-
The University of Texas at San Antonio Health Science Center pays non établi dans la noticeUniversité ou école supérieure
-
University of Maryland Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
-
Georgetown University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
-
Georgetown University Medical Center pays non établi dans la noticeÉtablissement de santé
-
Department of Neurology Dell Medical School at The University of Texas Austin Texas Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
-
Department of Neurology and Neurotherapeutics The University of Texas Southwestern Medical School Dallas Texas Department of Neurology and Neurotherapeutics pays non établi dans la noticeUniversité ou école supérieure
The University of Texas at Austin, National Institutes of Health et National Institute of Neurological Disorders and Stroke, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.