Accès ouvert déclaré 2019 article

Genome-wide association study of germline variants and breast cancer-specific mortality

Maria Escala-Garcia, Qi Guo, Thilo Dörk, Sander Canisius, Renske Keeman, Joe Dennis, Jonathan Beesley, Julie Lecarpentier, Manjeet K. Bolla, Qin Wang, Jean Abraham, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Paul L. Auer, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Bram Boeckx, Stig E. Bojesen, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Hiltrud Brauch, Hermann Brenner, Adam R. Brentnall, Louise A. Brinton, Per Broberg, Ian W. Brock, Sara Y. Brucker, Barbara Burwinkel, Carlos Caldas, Trinidad Caldés, Daniele Campa, Federico Canzian, Ãngel Carracedo, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Georgia Chenevix‐Trench, Ting‐Yuan David Cheng, Suet‐Feung Chin, Christine L. Clarke, Emilie Cordina‐Duverger, Fergus J. Couch, David G. Cox, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Janet Dunn, Alison M. Dunning, Lorraine Durcan, Miriam Dwek, Helena Earl, Arif B. Ekici, A. Heather Eliassen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Jonine D. Figueroa, Dieter Flesch‐Janys, Henrik Flyger, Marike Gabrielson, Manuela Gago-Domínguez, Eva Galle, Susan M. Gapstur, Montserrat García‐Closas, José Á. García-Sáenz, Mia M. Gaudet, Angela George, V. Georgoulias, Graham G. Giles, Gord Glendon, Anna González‐Neira, Grethe I.G. Alnæs, Mervi Grip, Pascal Guénel, Lothar Haeberle, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Patricia Harrington, Steven N. Hart, Jaana M. Hartikainen, Alexander Hein, Peter Hillemanns, Louise Hiller, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Guanmengqian Huang, Keith Humphreys, David J. Hunter, Wolfgang Janni, Esther M. John, Michael E. Jones, Arja Jukkola‐Vuorinen, Audrey Jung, Rudolf Kaaks, Maria Kabisch, Katarzyna Kaczmarek, Michael J. Kerin, Sofia Khan, Э. К. Хуснутдинова, Johanna I. Kiiski, Cari M. Kitahara, Julia A. Knight, Yon‐Dschun Ko, Linetta B. Koppert, Veli‐Matti Kosma, Peter Kraft, Vessela N. Kristensen, Ute Krüger, Tabea Kühl, Diether Lambrechts, Loı̈c Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Lian Li, Annika Lindblom, Sara Lindström, Martha S. Linet, Jolanta Lissowska, Wing‐Yee Lo, Sibylle Loibl, Jan Lubiński, Michael P. Lux, Robert J. MacInnis, Melanie Maierthaler, Tom Maishman, Enes Makalic, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Marı́a Elena Martı́nez, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Pooja Middha, Nicola Miller, Roger L. Milne, Fernando Moreno, Anna Marie Mulligan, Claire Mulot, Rami Nassir, Susan L. Neuhausen, Sune F. Nielsen, Børge G. Nordestgaard, Aaron D. Norman, Håkan Olsson, Nick Orr, V. Shane Pankratz, Tjoung‐Won Park‐Simon, José Ignacio Arias Pérez, Clara Pérez-Barrios, Paolo Peterlongo, Christos Petridis, Mila Pinchev, K. Prajzendanc, Ross L. Prentice, Nadège Presneau, Darya Prokofieva, Katri Pylkäs, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Rebecca Roylance, Emmanouil Saloustros, Elinor J. Sawyer, Daniel F. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Fredrick R. Schumacher, Lukas Schwentner, Rodney J. Scott, Christopher G. Scott, Caroline Seynaeve, Mitul Shah, Jacques Simard, Ann Smeets, Christof Sohn, Melissa C. Southey, Anthony J. Swerdlow, Aline Talhouk, Rulla M. Tamimi, William Tapper, Manuel R. Teixeira, Maria Tengström, Mary Beth Terry, Kathrin Thöne, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Diana Torres, Thérèse Truong, Constance Turman, Clare Turnbull, Hans-Ulrich Ulmer, Michael Untch, Celine M. Vachon, Christi J. van Asperen, Ans M.W. van den Ouweland, Elke M. van Veen, Camilla Wendt, Alice S. Whittemore, Walter C. Willett, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Yan Zhang, Douglas F. Easton, Peter A. Fasching, Heli Nevanlinna, Paul D.P. Pharoah, Marjanka K. Schmidt

72Citations signalées, ce qui n’est pas une note de qualité

169Institutions déclarées

23Pays d’affiliation déclarés

Rattachement africain : nl, gb, de, au, ca, us, es, ru, fi, se, be, dk, it, no, sa, fr, gr, pl, ie, il, cn, pt, co. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: , HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Genome-wide association study of germline variants and breast cancer-specific mortality
Date Crossref: 21/02/2019
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

The Netherlands Cancer Institute University of Cambridge Medizinische Hochschule Hannover QIMR Berghofer Medical Research Institute Cambridge University Hospitals NHS Foundation Trust Cancer Research UK Cambridge Center NIHR Cambridge Biomedical Research Centre Mount Sinai Hospital University of Toronto Lunenfeld-Tanenbaum Research Institute University of California, Irvine German Cancer Research Center Heidelberg University Fred Hutch Cancer Center University of Wisconsin–Milwaukee Universitätsklinikum Erlangen Milwaukee Health Department Comprehensive Cancer Center Erlangen Spanish National Cancer Research Centre Centre for Biomedical Network Research on Rare Diseases Russian Academy of Sciences Institute of Biochemistry and Genetics of Ufa Scientific Centre City of Hope Beckman Research Institute University of Helsinki Helsinki University Hospital Örebro University Hospital VIB-KU Leuven Center for Cancer Biology KU Leuven University of Copenhagen Copenhagen University Hospital Gentofte Hospital European Institute of Oncology Oslo University Hospital University of Oslo Akershus University Hospital Vestre Viken Hospital Trust Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Deutsches Konsortium für Translationale Krebsforschung University of Tübingen National Center for Tumor Diseases Queen Mary University of London National Cancer Institute Division of Cancer Epidemiology and Genetics Lund University University of Sheffield Institute of Cancer Research Instituto de Investigación Sanitaria del Hospital Clínico San Carlos Centro de Investigación Biomédica en Red de Cáncer University of Pisa King Abdulaziz University Universidade de Santiago de Compostela Fundación Pública Galega de Medicina Xenómica Instituto de Investigación Sanitaria de Santiago Servicio Gallego de Salud American Cancer Society Universität Hamburg University Medical Center Hamburg-Eppendorf University Cancer Center Hamburg Roswell Park Comprehensive Cancer Center The University of Sydney Westmead Institute for Medical Research Inserm Centre de recherche en Epidémiologie et Santé des Populations Mayo Clinic Centre de Recherche en Cancérologie de Lyon Mayo Clinic in Arizona Imperial College London Karolinska Institutet Fox Chase Cancer Center Leiden University Medical Center University of Warwick University of Southampton University of Westminster Brigham and Women's Hospital Harvard University Leipzig University Manchester Academic Health Science Centre University of Manchester St Mary's Hospital Edinburgh Cancer Research University of Edinburgh University of California San Diego Royal Marsden NHS Foundation Trust University Hospital of Heraklion The University of Melbourne Cancer Council Victoria Monash University Melbourne Health University of Utah Huntsman Cancer Institute Oulu University Hospital University of Oulu University of Cologne University Hospital Cologne University of Southern California Stockholm South General Hospital University of Massachusetts Amherst Amherst College Manchester University NHS Foundation Trust Wythenshawe Hospital NIHR Manchester Biomedical Research Centre Mayo Clinic in Florida University of Eastern Finland Kuopio University Hospital Krebsregister Saarland Erasmus MC Cancer Institute Cancer Research UK Manchester Institute University of Oxford Cancer Prevention Institute of California Stanford University Stanford Health Care Tampere University Hospital Tampere University Pomeranian Medical University National University of Ireland Bashkir State University Public Health Ontario Sinai Health System Johanniter-Krankenhaus Bonn University of Hawaiʻi at Mānoa University of Hawaii System Cancer Center of Hawaii University of Hawaii Cancer Center Carmel Medical Center Tianjin Medical University Cancer Institute and Hospital University of Washington Seattle University The Maria Sklodowska-Curie National Research Institute of Oncology German Breast Group Fondazione IRCCS Istituto Nazionale dei Tumori Karolinska University Hospital The Alfred Hospital Ludwig-Maximilians-Universität München University Health Network Sorbonne Paris Cité University of California, Davis Queen's University Belfast University of New Mexico Hospital Monte Naranco Hospital Universitario Puerta de Hierro Majadahonda IFOM Guy's Hospital King's College London King's College Hospital NordLab University Hospital of Larissa Case Western Reserve University John Hunter Hospital Hunter Medical Research Institute University of Newcastle Australia Centre hospitalier universitaire de Québec Université Laval Centre hospitalier de l'Université Laval Monash Health BC Cancer Agency University of British Columbia Vancouver General Hospital Universidade do Porto Instituto Português de Oncologia Francisco Gentil Columbia University Leiden University Centre for Human Genetics University of Birmingham Pontificia Universidad Javeriana Klinikum Mittelbaden Olgahospital Helios Hospital Berlin-Buch University of California, Los Angeles

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

BRCA gene mutations in cancerGenetic Associations and EpidemiologyGenomics and Rare Diseases

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