Accès ouvert déclaré
2019
article
Effects of blood pressure and lipid lowering on cognition
Jackie Bosch, Martin O’Donnell, Balakumar Swaminathan, Eva Lonn, Mikul Sharma, Gilles R. Dagenais, Rafael Díaz, Kamlesh Khunti, Basil S. Lewis, Álvaro Avezum, Claes Held, Mátyás Keltai, Christopher M. Reid, William D. Toff, Antonio Dans, Lawrence A. Leiter, Karen Sliwa, Shun Fu Lee, Janice M. Pogue, Robert G. Hart, Salim Yusuf, María Fernanda Alzogaray, Marina Blanco‐Aparicio, Martin Berli, Martina Bevacqua, M. Bustamante Labarta, B. Bustos, Alberto Caccavo, Alfonsina Candiello, Marcelo A. Carignano, Nuria Carrillo, N. Carro, Luis R Cartasegna, W. Casali, Arthur Justi Cassettari, Juan Pablo Cuello, Carlos Alberto Cuneo, Sandra Cusimano, C. Damonte, M. De Landaluc, Enrico De Martino, Raúl R. Rodrigues-Díez, Antonio Fernández, A. Ferrari, Louis Nuvagah Forti, Marcela Galello, Carlos García, Ruben Garcia Duran, Marcelo Garrido, Federico Giachello, Oscar Gómez Vilamajó, M. González, Fernando Guerlloy, Rodrigo Guerrero, Miguel Hominal, Adrian D. Hrabar, H. Imposti, Paulina Virginia Lanchiotti, Claudia Lauglé, Guillermo E Liniado, Marcos Litvak, Alessandra Longhi, Héctor Luciardi, Ian D.R. Mackinnon, R. Manzano, Julio C. S. Mariño, Barbara Merlo, R. Milesi, C. Mulazzi, Sergio Andrés Nemi, Silvia Ines Orio, MARIA JOSE PELAGAGGE, Sara Raimondi, Louis J. Rodino, Carlos J. Rodríguez, Laura R. Sago, Joan Sala, Anna Sánchez, Ramiro Sánchez, D. Santos, Pablo Schygiel, Virginia Sernia, Thomas W. Smith, Fernando Sökn, Leonardo Soso, Marcelo Trivi, Manuel Vico, Alberto S. Villamil, Dominik J. Vogel, Cesar Javier Zaidman, Walter P. Abhayaratna, J. Canalese, Henry Krum, Anushka Patel, Clarisse K. Brasil, C.B. Alves, Ana Rita Alves, José Carlos Aidar Ayoub, Luiz Carlos Corsetti Bergoli, Mariana Blacher, L. C. Bodanese, J.C.F. Braga, Osana Costa, M.K.M. Costa, Diego Faria, M.I. Del Monaco, L. Fabian Restelatto, Fernando Sergio Leitão Filho, Roberto Jorge da Silva Franco, Mariana Vargas Furtado, Paulo Leães, Lília Nigro Maia, José Antônio Marin‐Neto, E Mattar, Carine Mourão Melo, Flávia Mothé, Gustavo B.F. Oliveira, Eraldo Antônio Pelloso, Carísi Anne Polanczyk, Priscila Raupp da Rosa, S.O.C. Sales, José Francisco Kerr Saraiva, Arno Schmidt, Virgília S. Silva, A C Sousa, Adriana Polachini do Valle, Mário Wiehe, Beth L. Abramson, Sonia S. Anand, Juan Aw, William T. Baxter, Joseph Berlingieri, Jihoon Cha, Richard C. Chaulk, Tarini Chetty, D. Dattani, F Delage, Danielle Dion, M. Dominguez, Richard L. Gallo, K. Glendinning, Harold B. Goldman, Gilbert Gosselin, A. Greenspoon, Qi Ly, Martin Juneau, Patricia Keegan, Amanda K. Weiss Kelly, D. Kilby, M. Lavoi, Patrick Magloire, Puja K. Mehta, N. Mercante, H. Miscescu, Gabriel Morán, Shah Nawaz, Anil Nigam, Peter S. Pang, Előd Papp, Robert Petrella, C. Poirier, Rémi Rabasa‐Lhoret, Q. Rizvi, Dell D. Saulnier, Mukul Sharma, Parmjit Sohal, S Stern, Sheldon W. Tobe, Patrick Walsh, Richard Ward, Andrew Weeks, Vincent Woo, Jackie Yellin, P. Zuliani, Xue Bai, L.G. Dong, Yunyun Duan, JiaoJiao Feng, Ping Fu, Mingming Gao, P. Gao, Hai Ge, Yuan Ge, Qi Hua, D.J. Li, Xiaoli Liu, Xiaoding Liu, Zhidan Liu, Y.J. Liu, Feng‐Yuan Liu, L.H. Liu, Feng‐Hwa Lu, Tangfeng Lv, Shiwen Ma, Hao Ma, Ronghai Man, H Q Tan, Yu Shen, Jufang Shi, Xiaoyang Sun, Shouyang Wang, Baiqiao Wang, Y.Q. Wang, Yali Wei, X.C. Yang, Haijun Yang, Kun Yu, L.T. Yu, Jihong Yu, Wei Zhang, W. Zhang, F. Zhang, H.Y. Zhang, B. Zhang, Jingjing Zhao, Yiming Zhao, José Accini, E. Arcos, Gustavo Aroca, M. Casanova, Carlos Celemín, B. Coronel, Carlos Cotes, Carlos Curé, M. Diego-Olite, Alejandra Duarte, D. Escobar, M. Á. Figueredo, L. Garcia, Hector M. Garcia Garcia, Mauricio Alberto Grisales, Kristina Martinez, DORA INES MOLINA DE SALAZAR, B. Nino Castellanos, Ignacio J. Posada, Andres Quintero, Fernán González Bernaldo de Quirós, G. Sánchez, A Sotomayor, M L Buelga Suarez, Věra Adámková, Renata Cífková, Richard Ferkl, Markéta Galovcová, John R. Hartman, Marie Jozífová, KB Linhart, T Linhart, D. Moravčíková, Barbora Nussbaumerová, Martin Plachý, Hana Rosolová, Bohumil Seifert, Miroslav Souček, Yeni Vera, Mauricio Espinel, M. Lopez-Jaramillo, J. McDermont, Ernesto Peñaherrera, F. Plascencia, Freddy Pow-Chon-Long, Daniel Tettamanti, László Bajnok, É Baranyi, E. Bartfai, E. Bod, B. Bódis, István Czuriga, Erika Omega Huber, Emese Mezősi, Ferenc Poor, Éva Somos, Zita Tarjányi, T Tátrai, János Tomcsányi, András Vértes, András Zsáry, Dipesh Aggarwal, Katia Alexander, S Aman, Vageesh Ayyar, Yashwanth Balaji, Ganapati Bantwal, B. Bosco, Natarajan Chidambaram, Abhishek Dabra, Neeta Deshpande, H.R. Devendra, D. Ghoshroy, Sridevi Gnanasekaran, Rishi K Gupta, M.Z. Gutti, Gaurav Joshi, Sindhu Joshi, Shriprakash Kalantri, Arunima Kapoor, Ambreen Khan, RaghubirSingh Khedar, Aparna Manjunath, Keyur Kamlesh Mehta, Viswanathan Mohan, S. Murthy, Ashokan Nambiar, J.Bhargava Narendra J.Bhargava Narendra, Sanjoy K. Paul, M. A. Qureshi, S. Rajasekaran, K. Rangadham, Renāte Ranka, Roy S, M.R. Sathyanarayan, Kuppusamy Selvam, Jayaram Sethuraman, M. Shunmugvavelu, Gursukhmandeep Sidhu, Bhupinder Singh, Ram B. Singh, Nakul Sinha, J. Srinivas, A. Srinivas, B. Srinivasulu, Natalie Thomas, R Umarani, Kiron Varghese, S. Varma, S. Yelvatkar, A. Biton, Adiv Goldhaber, S. Ivri, Irina M. Shapiro, N. Shveydel, E. Shveydel, Daniel Tsalihin, Shlomo Vinker, Chaim Yosefy, K.H. Choe, Soo-Hyun Kim, D Ambigga, Mohd Aznan Aris, K.A. Ghapar, Chandramouli Krishnan, P. Mahadasa, M. Maizatullifah, Y. Mazapuspavina, Lakshmi Ramanathan, A. Shah Mohd Shah, Khalid Yusoff, J.H. Bonarius, Adam de Jong, Z. DeRuiter, René Devos, H.A. Dirkse, Emma Drenth, H. Ferguson, R.W.M.M. Jansen, Heinz-Theodor Mevissen, Hugo Rol, A. Schilder, Ida C. Spelt, P. VanLeeuwen, Maria Teresa B. Abola, HU Co, Adriano Mota Loyola, J. Mercado, D Morales, Luca Padua, Lia Palileo, A. Patanao, Guajardo Rodriguez Rogelio, Artemio Roxas, DENNIS JOSE SULIT, A. Tang-Manga, Bernadette A Tumanan-Mendoza, S. А. Boytsov, И. И. Чукаева, Karpov IuA, О. А. Кисляк, Ж. Д. Кобалава, A. Ledyacva, Yu. M. Lopatin, С. В. Недогода, Mariya Solovieva, В. В. Цома, T. V. Tyurina, Marián Hranai, Aysha Badat, Trevor Gerntholtz, Faris Al-Khalili, Bo Carlberg, Annika Dotevall, Peter M. Nilsson, Anneli Olsson, Annika Rosengren, Stefan Söderberg, Д.С. Артьомов, T. Babanina, A. E. Bagriy, S.V. Danyliuk, N. Doretska, O. Dorovska, Н. Довган, G. V. Dzyak, Л. В. Глушко, I. Gorbas, Т. О. Ілащук, K Karapetyan, І. Л. Караванська, Л. В. Хіміон, A. Khorsun, L. Kononenko, O. Kuryata, Olena Kvasha, Svetlana Lazareva, D. Loktyev, G. Lysenko, N. Miroshnchenko, O. Onyschenko, Alexander Parkhomenko, N. M. Petryk, С. А. Пивоварова, I. Rakytskay, L. V. Sapozhnychenko, I. Smymova, O.V. Soya, В. К. Тащук, N. A. Turubarova-Leunova, L. V. Vasilyeva, Natalia Velichko, Andriy Yagensky, Sachin Khunti, Ian Loke
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Résumé fourni par la source
OBJECTIVE: To assess whether long-term treatment with candesartan/hydrochlorothiazide, rosuvastatin, or their combination can slow cognitive decline in older people at intermediate cardiovascular risk. METHODS: The Heart Outcomes Prevention Evaluation-3 (HOPE-3) study was a double-blind, randomized, placebo-controlled clinical trial using a 2 × 2 factorial design. Participants without known cardiovascular disease or need for treatment were randomized to candesartan (16 mg) plus hydrochlorothiazide (12.5 mg) or placebo and to rosuvastatin (10 mg) or placebo. Participants who were ≥70 years of age completed the Digit Symbol Substitution Test (DSST), the modified Montreal Cognitive Assessment, and the Trail Making Test Part B at baseline and study end. RESULTS: Cognitive assessments were completed by 2,361 participants from 228 centers in 21 countries. Compared with placebo, candesartan/hydrochlorothiazide reduced systolic blood pressure by 6.0 mm Hg, and rosuvastatin reduced low-density lipoprotein cholesterol by 24.8 mg/dL. Participants were followed up for 5.7 years (median), and 1,626 completed both baseline and study-end assessments. Mean participant age was 74 years (SD ±3.5 years); 59% were women; 45% had hypertension; and 24% had ≥12 years of education. The mean difference in change in DSST scores was -0.91 (95% confidence interval [CI] -2.25 to 0.42) for candesartan/hydrochlorothiazide compared with placebo, -0.54 (95% CI -1.88 to 0.80) for rosuvastatin compared with placebo, and -1.43 (95% CI -3.37 to 0.50) for combination therapy vs double placebo. No significant differences were found for other measures. CONCLUSIONS: Long-term blood pressure lowering with candesartan plus hydrochlorothiazide, rosuvastatin, or their combination did not significantly affect cognitive decline in older people. CLINICALTRIALSGOV IDENTIFIER: NCT00468923. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for older people, candesartan plus hydrochlorothiazide, rosuvastatin, or their combination does not significantly affect cognitive decline.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of blood pressure and lipid lowering on cognition
- Date Crossref
- 26/03/2019
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Dementia and Cognitive Impairment ResearchLipoproteins and Cardiovascular HealthSodium Intake and Health