Upper extremity aerobic exercise training improves peak oxygen consumption in patients with pulmonary arterial hypertension

Le résumé fourni par la source

Background: Impaired oxygen uptake and utilization kinetics were reported in patients with pulmonary arterial hypertension (PAH). However, effects of upper extremity aerobic exercise training (AET) on peak oxygen consumption (peak-VO2kg) have not been investigated. Aim: This prospective, randomized controlled, double-blinded study investigates the effects of upper extremity AET on peak-VO2kg, cardiac and pulmonary outcomes and exercise capacity in PAH. Methods: Eleven patients in AET group (35.00±13.68years, 10F/1M) applied AET (55-75% of max-HR) 3 days/week and breathing exercises for 7 days/week and 11 patients in control group (40.18±14.47years, 10F/1M) applied breathing exercises for six weeks. Pulmonary functions (spirometry), exercise capacity (6-minute walk test [6MWT]), peak-VO2kg and cardiac and pulmonary outcomes (CPET during 6MWT) and dyspnea (modified “Medical Research Council” [MMRC] dyspnea scale) were evaluated before and after. Results: Baseline characteristics were similar in groups (p>0.05). Peak-VO2kg (Δ:2.03 vs -0.51 ml/min/kg, p=0.031), %peak-VO2kg (Δ:6.54% vs -2.36%, p=0.024) and MMRC (p<0.001) were significantly improved in AET group compared with controls. VE/VCO2 at AT (p=0.032) and %AT (p=0.009) were significantly impaired in controls compared with AET group. 6MWT distance was significantly and clinically increased (Δ=52.53m, 34% power); Heart rate reserve, VE and VT improved within AET group (p<0.05). Conclusions: Upper extremity AET improves oxygen consumption, cardiac and pulmonary outcomes; decreases dyspnea perception in PAH and should be included in cardiac rehabilitation programs. Further trials with more patients are needed.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.