Analysis of the solitary pulmonary nodule after surgical resection in patients using 18F-FDG integrated PET-CT scan at preoperative work-up

Le résumé fourni par la source

Objetives: To analyze after surgical resection the characteristics of patients operated on for solitary pulmonary nodule(SPN) up to 3cm in size with preoperative 18F-FDG integrated PET-CT scan and without diagnosis. Methodology: retrospective study of patients operated in the last 10 years. Dependent variable was histology result (benign vs malignant) of SPN. Variables of the study: age, sex, uptake on PET-CT scan, maximal standard uptake value(maxSUV), tobacco, chronic obstructive pulmonary disease(COPD), previous malignant disease, nodule size. Results: 305 patients were included in the study, 225(73.8%)male, 80(26.2%)women, mean age=63.9(rank 29-86), mean size of SPN=1.68cm(s.d. 0.65cm), benign=46(15.1%), malignant=258(84.6%), COPD=50.8%, previous malignancy=172 cases(56.4%), smoking=250 cases(82.0%), positive PET=280 cases(91.8%), median maxSUV=3.4(rank 0-20.7). Binary logistic regression model by backward steps showed age, maxSUV, previous malignant disease, and female sex were statistically significant risk factors (p<0.05, table-1). Area under the curve was 0.804; for cutoff point 0.536 sensitibity and specificity were 97.2% and 34.8% respectively. Respect to maxSUV, area under the curve was 0.694; for cutoff point 1.1 sensitibity and specificity were 90.2% and 30.4% respectively. Conclusions: age, SUVmax, medical history of previous malignant disease, and female were independent risks factors in our analysis of patients operated on for SPN.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.