Synaptic distributions of pS214‐tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline
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Le résumé fourni par la source
Female rhesus monkeys and women are subject to age- and menopause-related deficits in working memory, an executive function mediated by the dorsolateral prefrontal cortex (dlPFC). Long-term cyclic administration of 17β-estradiol improves working memory, and restores highly plastic axospinous synapses within layer III dlPFC of aged ovariectomized monkeys. In this study, we tested the hypothesis that synaptic distributions of tau protein phosphorylated at serine 214 (pS214-tau) are altered with age or estradiol treatment, and couple to working memory performance. First, ovariectormized young and aged monkeys received vehicle or estradiol treatment, and were tested on the delayed response (DR) test of working memory. Serial section electron microscopic immunocytochemistry was then performed to quantitatively assess the subcellular synaptic distributions of pS214-tau. Overall, the majority of synapses contained pS214-tau immunogold particles, which were predominantly localized to the cytoplasm of axon terminals. pS214-tau was also abundant within synaptic and cytoplasmic domains of dendritic spines. The density of pS214-tau immunogold within the active zone, cytoplasmic, and plasmalemmal domains of axon terminals, and subjacent to the postsynaptic density within the subsynaptic domains of dendritic spines, were each reduced with age. None of the variables examined were directly linked to cognitive status, but a high density of pS214-tau immunogold particles within presynaptic cytoplasmic and plasmalemmal domains, and within postsynaptic subsynaptic and plasmalemmal domains, accompanied high synapse density. Together, these data support a possible physiological, rather than pathological, role for pS214-tau in the modulation of synaptic morphology in monkey dlPFC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Synaptic distributions of pS214‐tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline
- Date Crossref
- 04/12/2018
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Allen Institute for Brain Science pays non établi dans la noticeStructure de recherche
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Icahn School of Medicine at Mount Sinai Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories pays non établi dans la noticeUniversité ou école supérieure
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National Institute on Aging pays non établi dans la noticeStructure de recherche
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University of California pays non établi dans la noticeUniversité ou école supérieure
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Friedman Brain Institute New York New York pays non établi dans la noticeStructure de recherche
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California National Primate Research Center Davis California pays non établi dans la noticeStructure de recherche
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Graduate School of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
Allen Institute for Brain Science, Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories — Icahn School of Medicine at Mount Sinai et National Institute on Aging, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.