A10383 Towards an Implantable Telemetry System for Photoplethysmography Based Vital Signs Monitoring in Small Animals

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Objectives: Resistant hypertension persists and affects 20% to 30% of all hypertensive patients for which alternative treatment strategies are explored. Increasing attention is given to the sympathetic nervous system (SNS) in the pathogenesis of hypertension. The interruption of the renal SNS by catheter-based denervation has been studied. Another approach may be Baroreflex activation where electrical stimulation of carotid sinus- and aortic arch baroreceptors evokes a reduction in sympathetic neural traffic to the heart, vasculature, kidneys, etc. We have recently reported on ongoing work towards a platform for implantable telemetry devices which includes a versatile Photoplethysmography (PPG) subsystem as well as neuro-stimulation and –recording capabilities. To date, no arterial oxygenation (SpO2) telemetry solution exists for implantation in rodents. Methods: An optical probe is placed during acute animal experiments on the carotid artery of a rat. From the obtained PPG signals, SpO2, heart rate, respiratory cycle, and pulse wave velocity (PWV) are extracted. Also, PPG-based estimation of diastolic blood pressure (DBP) and pulse pressure (PP) is investigated. Results: Our preliminary results confirm that monitoring of arterial oxygenation, heart rate, and respiratory cycle is possible with our setup; further work is required for PWV and thereon based DBP and PP estimation. Conclusion: The interdependence of recorded PPG signals with targeted vital signs was tested in acute in-vivo experiments, yielding encouraging results; sufficient miniaturization for implantation in small animals is feasible. The envisioned device could be an interesting tool in cardiovascular and hypertension research – especially in research on alternative hypertension treatment strategies. The work was partially supported by SNF-NanoTera

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