Accès ouvert déclaré 2018 article

Declining Incidence of Invasive Meningococcal Disease in South Africa: 2003–2016

Susan T. Meiring, Cheryl A. Cohen, Linda de Gouveia, Mignon du Plessis, Ranmini S. Kularatne, Anwar Ahmed Hoosen, Ruth Lekalakala, Sarona Lengana, Sharona Seetharam, Preneshni R. Naicker, Vanessa Cecilia Quan, Gary Reubenson, Stefano Tempia, Claire von Mollendorf, Anne von Gottberg, John M. Black, Vanessa Pearce, Vicky Kleinhans, Alan Karstaedt, Caroline Maluleka, Charl Verwey, Charles H. Feldman, David M. Moore, Khine Swe Swe-Han, Jeannette Wadula, Jeremy Stephen Nel, Kathy Lindeque, Maphoshane Nchabeleng, Nazlee Samodien, Nicolette du Plessis, Norma Bosman, Teena Thomas, Theunis Avenant, Trusha Nana, Vindana Chibabhai, Adhil Maharj, Asmeeta Burra, Fathima Naby, Halima Dawood, Jade Mogamberry, Koleka Patience Mlisana, Lisha Sookan, Praksha Ramjathan, Prasha Mahabeer, Romola Naidoo, Sumayya Haffejee, Yacoob Mahomed Coovadia, Ken Hamese, Ngoaka Sibiya, Greta Hoyland, Jacob Lebudi, Pieter L. Jooste, Ebrahim Variava, Erna du Plessis, Andrew Christopher Whitelaw, Kessendri Reddy, Mark Patrick Nicol, Adrian John Brink, Elizabeth Prentice, Inge Zietsman, M.L. Botha, Peter M. Smith, Xoliswa Poswa, Chetna Narsai Govind, Keshree Pillay, Suzy Budavari, Catherine Samuel, Marthinus Senekal, Andries William Dreyer, Khatija Ahmed, Louis J. Marcus, Warren Lowman, Angeliki P. Messina, Dena van den Bergh, Karin M. A. Swart, Cynthia G. Whitney, Keith P. Klugman, Ananta Nanoo, Anthony Marius Smith, Arvinda Sooka, Cecilia Miller, Charlotte Sriruttan, Chikwe A Ihekweazu, Desiree du Plessis, Erika Britz, Frans M. Radebe, Genevie M. Ntshoe, GILLIAN M. HUNT, Hlengain Mathema, Jacqueline Weyer, John Frean, Karen Helena Keddy, Kerrigan McCarthy, Linda Erasmus, Lucille Hellen Blumberg, Marshagne Smith, Martha Makgoba, Motshabi Modise, Nazir Ahmed Ismail, Nelesh Premapragasan Govender, Neo Legare, Nicola Anne Page, Ntsieni Ramalwa, Nuraan Paulse, Phumeza Vazi, Olga Perovic, Penny Crowther-Gibson, Portia Mutevedzi, Riyadh Manesen, Ruth S. Mpembe, Shabir Ahmed Madhi, Sibongile Walaza, Sonwabo Lindani, Sunnieboy Njikho, Thejane Motladiile, Tiisetso Lebaka, Verushka Chetty

16Citations signalées, ce qui n’est pas une note de qualité

7Institutions déclarées

3Pays d’affiliation déclarés

Rattachement africain : Afrique du Sud, us, Éthiopie. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

BACKGROUND: Invasive meningococcal disease (IMD) is endemic to South Africa, where vaccine use is negligible. We describe the epidemiology of IMD in South Africa. METHODS: IMD cases were identified through a national, laboratory-based surveillance program, GERMS-SA, from 2003-2016. Clinical data on outcomes and human immunodeficiency virus (HIV) statuses were available from 26 sentinel hospital sites. We conducted space-time analyses to detect clusters of serogroup-specific IMD cases. RESULTS: Over 14 years, 5249 IMD cases were identified. The incidence was 0.97 cases per 100 000 persons in 2003, peaked at 1.4 cases per 100 000 persons in 2006, and declined to 0.23 cases per 100 000 persons in 2016. Serogroups were confirmed in 3917 (75%) cases: serogroup A was present in 4.7% of cases, B in 23.3%, C in 9.4%; W in 49.5%; Y in 12.3%, X in 0.3%; Z in 0.1% and 0.4% of cases were non-groupable. We identified 8 serogroup-specific, geo-temporal clusters of disease. Isolate susceptibility was 100% to ceftriaxone, 95% to penicillin, and 99.9% to ciprofloxacin. The in-hospital case-fatality rate was 17% (247/1479). Of those tested, 36% (337/947) of IMD cases were HIV-coinfected. The IMD incidence in HIV-infected persons was higher for all age categories, with an age-adjusted relative risk ratio (aRRR) of 2.5 (95% confidence interval [CI] 2.2-2.8; P < .001) from 2012-2016. No patients reported previous meningococcal vaccine exposure. Patients with serogroup W were 3 times more likely to present with severe disease than those with serogroup B (aRRR 2.7, 95% CI 1.1-6.3); HIV coinfection was twice as common with W and Y diseases (aRRR W = 1.8, 95% CI 1.1-2.9; aRRR Y = 1.9, 95% CI 1.0-3.4). CONCLUSIONS: In the absence of significant vaccine use, IMD in South Africa decreased by 76% from 2003-2016. HIV was associated with an increased risk of IMD, especially for serogroup W and Y diseases.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Declining Incidence of Invasive Meningococcal Disease in South Africa: 2003–2016
Date Crossref: 23/10/2018
Éditeur: Oxford University Press (OUP)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

National Health Laboratory Service Afrique du Sud (code pays fourni par la source)
Organisme public
University of the Witwatersrand University of the Witwatersrand, Afrique du Sud (code pays fourni par la source)
Université ou école supérieure
University of Limpopo Department of Medical Microbiology University of Limpopo, Afrique du Sud (code pays fourni par la source)
Université ou école supérieure
Lancet Laboratories Johannesburg, Afrique du Sud (code pays fourni par la source)
Structure de recherche
University of Cape Town Division of Medical Microbiology University of Cape Town, Afrique du Sud (code pays fourni par la source)
Université ou école supérieure
Centers for Disease Control and Prevention pays non établi dans la notice
Organisme public
Africa Centres for Disease Control and Prevention Éthiopie (code pays fourni par la source)
Organisation à but non lucratif
National Institute for Communicable Diseases (NICD) Division of Public Health Surveillance and Response Johannesburg, Afrique du Sud (ville ou établissement reconnu, pays non nommé)
Structure de recherche
School of Public Health University of the Witwatersrand, Afrique du Sud (ville ou établissement reconnu, pays non nommé)
Université ou école supérieure
Centre for Respiratory Diseases and Meningitis Johannesburg, Afrique du Sud (ville ou établissement reconnu, pays non nommé)
Institution
Centre for HIV and STI Johannesburg, Afrique du Sud (ville ou établissement reconnu, pays non nommé)
Institution
Free State Province Afrique du Sud (pays nommé en fin d’affiliation)
Institution

National Health Laboratory Service (Afrique du Sud), University of the Witwatersrand (University of the Witwatersrand, Afrique du Sud) et Department of Medical Microbiology — University of Limpopo (University of Limpopo, Afrique du Sud), avec 9 autres affiliations. Pays d’affiliation : Afrique du Sud, Éthiopie.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Bacterial Infections and VaccinesVirology and Viral DiseasesHerpesvirus Infections and Treatments

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