Abstract TP7: Effect of Tissue Plasminogen Activator or Endovascular Thrombectomy for Mortality of Acute Ischemic Stroke in Nationwide Hospital Cohort : J-ASPECT Study
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Le résumé fourni par la source
Introduction: In recent years, the treatment of the acute phase of cerebral infarction such as tPA and endovascular thrombectomy has been rapidly changing, and development of a medical system for acute cerebral infarction is desired. Objective: To examine the effect of tPA and endovascular thrombectomy on mortality in patients with acute ischemic stroke in the nationwide 5 years hospital cohort in Japan. Methods: We conducted annual nationwide survey from 2011 to 2015 using data from the Japanese Diagnosis Procedure Combination database on patients hospitalized with ischemic and hemorrhagic stroke in a nationwide hospital cohort in Japan (J-ASPECT Study). The effect of tPA or endovascular thrombectomy on stroke mortality was analyzed by mixed effect model with years (from 2011 to 2015), age, gender, Japan Coma Scale (JCS), and Comprehensive stroke care (CSC) score as a fixed effect, and hospital as a random effect. CSC score was developed by our study group based on the institutional survey conducted in 2011. Results: The total numbers of patients were 292,230 in ischemic stroke. In 5 years, the proportion of tPA or endovascular thrombectomy has increased from 7.2% to 8.4%, while the mortality has decreased from 7.6% to 5.5%. The mortality varied by JCS, which was 37.5% for JCS 3 digit, 15.4% for JCS 2 digit, 4.8% for JCS 1 digit and 1.4% for JCS 0 in 2015. In the analysis of subjects with severe JCS 3 digit, years (OR = 0.97, 95% CI = 0.94 - 1.00), CSC score increase (0.98, 95% CI = 0.97 - 0.99), and tPA or endovascular thrombectomy (OR = 0.75, 95% CI = 0.67 - 0.84) were found to reduce the risk of death. Conclusion: According to the analysis of patients with acute ischemic stroke for 5 years, tPA or endovascular thrombectomy was related to reduced mortality in subjects with high severity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstract TP7: Effect of Tissue Plasminogen Activator or Endovascular Thrombectomy for Mortality of Acute Ischemic Stroke in Nationwide Hospital Cohort : J-ASPECT Study
- Date Crossref
- 22/01/2018
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kyushu University Graduate Sch of Med Sciences pays non établi dans la noticeUniversité ou école supérieure
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National Cerebral and Cardiovascular Center pays non établi dans la noticeÉtablissement de santé
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National Cancer Centre Japan pays non établi dans la noticeÉtablissement de santé
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Satou Hospital pays non établi dans la noticeÉtablissement de santé
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Daiichi Sankyo (United States) pays non établi dans la noticeEntreprise
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Nara Medical University pays non établi dans la noticeUniversité ou école supérieure
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Izumi City General Hospital pays non établi dans la noticeÉtablissement de santé
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Kokura Memorial Hospital pays non établi dans la noticeÉtablissement de santé
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University of Occupational and Environmental Health Japan pays non établi dans la noticeUniversité ou école supérieure
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The Nakamura Hajime Eastern Institute pays non établi dans la noticeStructure de recherche
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Suzuki (Japan) pays non établi dans la noticeEntreprise
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Research Institute for Brain and Blood Vessels Akita pays non établi dans la noticeStructure de recherche
Graduate Sch of Med Sciences — Kyushu University, National Cerebral and Cardiovascular Center et National Cancer Centre Japan, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.