Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles

Résumé fourni par la source

We report the use of air-stable Cu(I)-NHC complex 4a as a catalyst for the efficient microwave-assisted synthesis of peptidotriazoles on solid phase. Compared with the usual conditions (CuI or CuSO 4 /NaAsc), catalyst 4a allowed the preparation of a series of peptidomimetic compounds containing a 1,2,3-triazole ring in their backbone without the oxidation of common side-chains. Overall, the peptidotriazoles were obtained in good yields (61–87%), in excellent purity (higher than 94%) and with low copper contamination.

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