Accès ouvert déclaré
2018
article
Pre-ART HIV-1 DNA in CD4+ T cells correlates with baseline viro-immunological status and outcome in patients under first-line ART
Francesca Ceccherini‐Silberstein, Alessandro Cozzi‐Lepri, Claudia Alteri, Esther Merlini, Matteo Surdo, Giulia Marchetti, Maria Rosaria Capobianchi, Andrea De Luca, Nicola Gianotti, Pierluigi Viale, Massimo Andreoni, Andrea Antinori, Carlo Federico Perno, Antonella d’Arminio Monforte, Antonella Castagna, Francesco Castelli, Roberto Cauda, Giovanni Di Perri, Massimo Galli, R Iardino, Giuseppe Ippolito, Adriano Lazzarin, G Rezza, F von Schloesser, Enrico Girardi, Sergio Lo Caputo, Cristina Mussini, Massimo Puoti, Adriana Ammassari, Claudia Balotta, Alessandra Bandera, Paolo Bonfanti, Stefano Bonora, Marco Borderi, Andrea Calcagno, Leonardo Calza, Antonella Cingolani, Paola Cinque, Antonio Di Biagio, Andrea Gori, Giovanni Guaraldi, Giuseppe Lapadula, Miriam Lichtner, Giordano Madeddu, Franco Maggiolo, S Marcotullio, Laura Monno, Silvia Nozza, Eugenia Quirós-Roldán, Roberto Rossotti, Stefano Rusconi, Maria Mercedes Santoro, Annalisa Saracino, Mauro Zaccarelli, Iuri Fanti, Laura Galli, P Lorenzini, A Rodano, Milensu Shanyinde, A Tavelli, Fabrizio Carletti, Silvia Carrara, Antonino Di, Silvia Graziano, Fabrizio Petrone, Gennaro Prota, Serena Quartu, S Truffa, A Giacometti, Andrea Costantini, V Barocci, Gioacchino Angarano, Carmen Rita Santoro, Claudia Suardi, Valentina Donati, Gabriella Verucchi, C Minardi, Tiziana Quirino, C Abeli, Paolo Emilio Manconi, P Piano, Bruno Cacopardo, Benedetto Maurizio Celesia, J Vecchiet, Katia Falasca, L Sighinolfi, Daniela Segala, Pierluigi Blanc, Francesca Vichi, Giovanni Cassola, Claudio Viscoli, A. Alessandrini, Nicoletta Bobbio, Giovanni Mazzarello, Claudio Maria Mastroianni, Irene Pozzetto, Chiara Molteni, Alessandro Chiodera, P Milini, Giuseppe Nunnari, Giovanni Francesco Pellicanò, Gloria Montenegro Rizzardini, M C Moioli, R. Piolini, Anna Lisa Ridolfo, S Salpietro, Camilla Tincati, Cinzia Puzzolante, Antonio Chirianni, Guglielmo Borgia, Vincenzo Esposito, Rosalba Orlando, Giovanni Bonadies, Federica Martino, Ivan Gentile, L Maddaloni, Anna Maria Cattelan, Serena Marinello, Antonio Cascio, Claudia Colomba, Franco Baldelli, Elisabetta Schiaroli, Giustino Parruti, F Sozio, G. Magnani, M A Ursitti, R Acinapura, Gianmaria Baldin, M Capozzi, Stefania Cicalini, Alfonso Cristaudo, Lucia Fontanelli Šuleková, Giancarlo Iaiani, Alessandra Latini, Ilaria Mastrorosa, Maria Maddalena Plazzi, Stefano Savinelli, Alessandra Vergori, Vincenzo Vullo, M Cecchetto, Franco Viviani, Paola Bagella, Barbara Rossetti, Anaïs Franco‐Romero, Rosario Vecchio, Daniela Francisci, C Di Giuli, P Caramello, Giancarlo Orofino, Mariangela Sciandra, Matteo Bassetti, AP Londero, G. Pellizzer, Vinicio Manfrin, Giulio Starnini, A Ialungo
12Citations signalées — pas une note de qualité
10Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
Objectives: We evaluated the association between pre-ART HIV DNA and HIV-infected participant characteristics at baseline as well as with their response to first-line ART. Methods: Four hundred and thirty-three patients from the ICONA cohort, starting first-line ART after the year 2000, were analysed. Pre-ART HIV DNA was quantified with the modified COBAS TaqMan HIV-1 Test and normalized by CD4+ T cells. Linear correlation between pre-ART HIV DNA and other continuous markers (HIV RNA, CD4 count, markers of inflammation and coagulation) at baseline was evaluated by means of Pearson correlation coefficient and a linear regression model. Survival analyses and Cox regression models were used to study the association between pre-ART HIV DNA and time to viro-immunoclinical events. Results: Pre-ART HIV DNA [median (IQR): 10 702 (3397-36 632) copies/106 CD4+ T cells] was correlated with pre-ART HIV RNA [R2 = +0.44, (P < 0.0001)], CD4+ T cells [R2 = -0.58, (P < 0.0001)] and CD4/CD8 ratio [R2 = -0.48, (P < 0.0001)], while weaker correlations were observed with CD8+ T cells (R2 = -0.20, P = 0.01), IL-6 (R2 = +0.16, P = 0.002) and soluble CD14 (R2 = +0.09, P = 0.05). Patients with higher pre-ART HIV DNA showed lower rate and delayed virological response (defined as HIV RNA ≤50 copies/mL), compared with those having lower HIV DNA (67.2% for >10 000, 81.1% for 1000-10 000 and 86.4% for 10-1000 copies/106 CD4+ T cells; P = 0.0004). Higher pre-ART HIV DNA was also correlated with increased risk of virological rebound (defined as HIV RNA >50 copies/mL) by 24 months (17.2% for >10 000, 7.4% for 1000-10 000 and 4.3% for 10-1000 copies/106 CD4+ T cells; P = 0.0048). Adjusted HRs of all virological rebound definitions confirmed these findings (P ≤ 0.02). Conclusions: Pre-ART HIV DNA, along with HIV RNA and CD4+ T cell count, should be considered as a new staging marker to better identify people at lower (or higher) risk of viral rebound following achievement of virological suppression (≤50 copies/mL).
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pre-ART HIV-1 DNA in CD4+ T cells correlates with baseline viro-immunological status and outcome in patients under first-line ART
- Date Crossref
- 20/09/2018
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
HIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions