Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents
Rattachement africain : ru, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Essential arterial hypertension (EAH) in adolescents represents a social burden. The endothelium is involved in the pathogenesis of EAH. Imbalance of key vasoactive factors - namely nitric oxide (NO) and endothelin-1 (ET-1) - is observed, and serotonin (5-HT) release is also impaired. The relationship between the factors and high blood pressure (BP) has been established mainly in preclinical studies and in the adult age. The aim of the present manuscript is to establish the association between plasma ET-1, serum NO and 5-HT, platelet 5-HT levels and BP in male adolescents, analyzing their concentrations in controls, prehypertensive and hypertensive children. Consequently, we want to evaluate ET-1, NO and 5-HT levels as preclinical biomarkers of EAH. METHODS: Outpatient adolescents, examined at Children's Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, were recruited between 26th of May and 25th of September 2016. Predictor variables identified were plasma ET-1, serum NO and 5-HT levels and were evaluated in serum and platelets of case and control groups. RESULTS: Plasma ET-1 and serum 5-HT concentrations in prehypertensive and hypertensive children were higher than in controls, with hypertensive adolescents showing higher levels of both factors compared with prehypertensive adolescents. Platelet 5-HT levels were lower in prehypertensive and hypertensive children compared with controls, while serum NO levels were higher in prehypertensive children than in hypertensive children. CONCLUSION: Measurable ET-1, NO and 5-HT are related to BP in adolescents and may serve as diagnostic biomarkers of EAH. Furthermore, they could help to better define prehypertensive and hypertensive children.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents
- Date Crossref
- 01/09/2018
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Kazan State Medical University Department of Normal Physiology pays non établi dans la noticeUniversité ou école supérieure
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Kazan State Medical Academy pays non établi dans la noticeUniversité ou école supérieure
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Koltzov Institute of Developmental Biology pays non établi dans la noticeStructure de recherche
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Magna Graecia University pays non établi dans la noticeUniversité ou école supérieure
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Accademia di Belle Arti di Catanzaro pays non établi dans la noticeUniversité ou école supérieure
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Department of Hospital Pediatrics pays non établi dans la noticeÉtablissement de santé
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Koltsov Institute of Developmental Biology pays non établi dans la noticeStructure de recherche
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Interuniversity Center of Phlebolymphology (CIFL) Department of Vascular Surgery pays non établi dans la noticeUniversité ou école supérieure
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University of Catanzaro Department of Medical and Surgical Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Pediatrics — Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Department of Normal Physiology — Kazan State Medical University et Kazan State Medical Academy, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.