P4553Urinary NGAL-guided risk assessment for adverse kidney-related events after open heart surgery

Résumé fourni par la source

Background: Early assessment of risk for major adverse kidney-related events (MAKE) and acute kidney injury (AKI) by the treating physician is part of routine care in open-heart surgery patients. Accordingly, the most recent acute kidney injury (AKI) clinical practice guidelines emphasize the importance of achieving the earliest possible identification of such risk. Combined novel kidney injury biomarkers and clinical information (CB&CI) based prediction of MAKE and AKI is now possible but its superiority over conventional clinical assessment (CCA) is uncertain. This study assesses the accuracy of prediction of MAKE and AKI using CB&CI compared with CCA using the category free net reclassification index (cfNRI). Methods: In an exploratory cohort of open-heart surgery patients, we compared ability of CB&CI based on urinary neutrophil gelatinase-associated lipocalin (NGAL) values at ICU admission with CCA in predicting MAKE and acute kidney injury (AKI). In an independent subsequent prospective validation cohort, MAKE and AKI were predicted at the bedside immediately after postoperative ICU admission either with CB&CI or CCA.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.