P2492Baroreflex activation therapy in heart failure with reduced ejection fraction improves cardiopulmonary function during exercise

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Introduction: Baroreflex activation therapy (BAT) has favourable effects on clinical status and quality of life in patients with heart failure with reduced ejection fraction (HFrEF) by improving autonomic dysbalance. To date, little is known about the mechanisms of clinical improvement, and about the influence of BAT on cardiopulmonary function during exercise. Therefore, we performed cardiopulmonary exercise testing (CPET) before and after initiation of BAT. Methods: Twelve patients with HFrEF were treated with the second generation BAT system at our center. Initial eligibility criteria for BAT were New York Heart Association (NYHA) class ≥III and an ejection fraction ≤35% on stable guideline-directed medical and device therapy. Patients underwent CPET before and after initiation of BAT as part of the routine heart failure diagnostic investigations. Relevant parameters of maximal exercise capacity as well as circulatory and ventilatory efficiency were analysed. Data were tested for statistical significance by Wilcoxon test and are presented as mean ± standard deviation.

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