Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda
Rattachement africain : us, Ouganda. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Onchocerciasis a neglected tropical disease that historically has been a major cause of morbidity and an obstacle to economic development in the developing world. It is caused by infection with Onchocerca volvulus, which is transmitted by black flies of the genus Simulium. The discovery of the potent effect of Mectizan (ivermectin) on O. volvulus microfilariae and the decision by its manufacturer to donate the drug for onchocerciasis spurred the implementation of international programs to control and, more recently, eliminate this scourge. These programs rely primarily on mass distribution of ivermectin (MDA) to the afflicted populations. However, MDA alone will not be sufficient to eliminate onchocerciasis where transmission is intense and where ivermectin MDA is precluded by co-endemicity with Loa loa. Vector control will likely be required as a supplemental intervention in these situations. METHODOLOGY/PRINCIPAL FINDINGS: Because biting by the black fly vectors is often a major nuisance in onchocerciasis afflicted communities, we hypothesized that community members might be mobilized to clear the breeding sites of the vegetation that represents the primary black fly larvae attachment point. We evaluated the effect of such a community based "slash and clear" intervention in multiple communities in Northern Uganda. Slash and Clear resulted in 89-99% declines in vector biting rates. The effect lasted up to 120 days post intervention. CONCLUSIONS/SIGNIFICANCE: Slash and clear might represent an effective, inexpensive, community- based tool to supplement ivermectin distribution as a contributory method to eliminate onchocerciasis and prevent recrudescence.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda
- Date Crossref
- 27/08/2018
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of South Florida pays non établi dans la noticeUniversité ou école supérieure
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National Water and Sewerage Corporation Ouganda (code pays fourni par la source)Organisme public
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Ministry of Health Vector Control Division Kampala, Ouganda (code pays fourni par la source)Organisme public
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University of Alabama at Birmingham pays non établi dans la noticeUniversité ou école supérieure
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Auburn University Department of Entomology and Plant Pathology pays non établi dans la noticeUniversité ou école supérieure
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College of Public Health Department of Global Health pays non établi dans la noticeUniversité ou école supérieure
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Nwoya District Local Government Ouganda (pays nommé en fin d’affiliation)Institution
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School of Public Health Department of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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The Carter Center Kampala, Ouganda (pays nommé en fin d’affiliation)Institution
University of South Florida, National Water and Sewerage Corporation (Ouganda) et Vector Control Division — Ministry of Health (Kampala, Ouganda), avec 6 autres affiliations. Pays d’affiliation : Ouganda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.