Accès ouvert déclaré
2018
article
Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme
Colin R. Lindsay, Emily Shaw, Fiona Blackhall, Kevin G. Blyth, James D. Brenton, Anshuman Chaturvedi, Noel W. Clarke, Craig Dick, T.R.J. Evans, Geoff Hall, Andrew M. Hanby, David J. Harrison, Stephen R.D. Johnston, Malcolm D. Mason, Dion Morton, Julia Newton‐Bishop, Andrew G. Nicholson, Karin A. Oien, Sanjay Popat, Doris M. Rassl, Rowena Sharpe, Phillipe Taniere, Ian Walker, William Wallace, Nicholas P. West, Rachel Butler, David González de Castro, Mike Griffiths, Peter Johnson, Pauline Rehal, Samantha Butler, Matthew Smith, Rachel Doak, Anna Tańska, Graham Halford, Lisa M. James, Chris Kotara, G Masson, Samuel Clokie, Jennie Bell, Fiona MacDonald, Lisa Thompson, Debbie Mair, Suzanne Lillis, Dörte Wren, R D Hollifield, Keeda Dover, Manisha Maurya, D. Brooks, Belen Gomez, Lisa Grady, Thomas Jones, Chantal Hooper, Daphne Webster, Jolyon Travis, Stephanie Ogwuru, Jana Gazdová, Denise Collins, Elaine Chapman, Lisa Leavey, Paula Proszek, Sanna Hulkki, V. Peter Collins, A. A. Ibrahim, Kat Brown, Jo Burge, Karen Burnett, Ginny Devonshire, E. Moseley, Bev Haynes, Charlotte Hodgkin, M. Jimenez-Linan, Linda A. Jones, Gilly Kenyon, Betania Mahler‐Araujo, Karen Payne, Jo Piper, Sue Richardson, Ed Rytina, Anne Y. Warren, L. H. Coker, Gemma Godsall, Mark J. Arends, Amanda O’Neill, K. Rintoul, Goymer Donna, Julie K. Taylor, Claire Matthews, Harshil Bhayani, Tina Osalador, Zakiya Niwaz, A.J. Higgins, Olivia Bamsey, Janine Salter, L Renouf, Glenn Noel-Storr, Helen Roberts, Kasia Gierejko, Paola Knapman, Andrew Wotherspoon, Gordon Stamp, Ayoma Attygailye, Steve Hazell, Peter Osin, A Nerurkar, Steven Francis, Marion Runde, J. Arch, Xavier Chitnis, Bernard F. Siu, Debra Townsend, Laura Hennelly, Natalie Taylor, Bernadette Johnson, Susie Banerjee, L Pyle, Monica Hamill, Jenny Gyertson, Angela George, Krishna Patel, Karla Pearce, Kim Edmonds, Sarah Sarker, Rosalind A. Eeles, Liz Bancroft, Sarah Thomas, Yukie Kano, Lisa J. Rowland, Karen Brooks, Mary O’Brien, Jaishree Bhosle, Kathy Priest, Bee Ayite, Jo Severn, Helen Beedham, Nicky Lucas, A. Lorentzos, Janine Webb, Sarah Kerr, Lisa Corestav, Diego Bottero, Laura Jell, Janet Thomas, Cheryl Marriott, Neil Rajah, Andy Cole, Dieu Ly, Philippe Tanière, Brendan O’Sullivan, C.G. Swift, Frances Hughes, Desley Neil, Dolapo Ajayi, Alison Barclay, Debbie Beirne, Andrew C. Bernard, Maxine Berry, Jo Bentley, D. Timothy Bishop, Amy Chambers, Jude Clarke, Anne Crossley, Narinder Gahir, Debbie Gibson, Rona Good, Konstantina Grosios, P. Harnden, Kate Hasler, Damien Hindmarch, Sharon Jackson, Colin Johnstone, Anne-marie Jones, Gil Lambert, Sally Lane, Nicola Mcnicholas, Rebecca Millican‐Slater, Cath Moriaty, Alex Newsham, Kara O’connell, Lisa Ripley, David Sebag‐Montefiore, Mary M. Simpson, V. Speirs, Joh Sugden, Lauren Tate, Emma Tidswell, Chris Twelves, Christy Walker, Barry D. Waterhouse, Martin Waugh, Louise G. White, E. M. Wright, Jane Rogan, Garry Ashton, Caron Abbey, Michelle Greenhalgh, Daisuke Nonaka, E. Shing, Carmen Gibbard, Georgina Burton, Naomi Fawkes, A. T. H. Marsden, Rachael Waddington, Phil Harrison, Shahrzad Moghadam, Kate Murray, Christy Mitchinson, Richard Booton, Rajesh Shah, Anca Oniscu, Frances Rae, Craig Marshall, Linda Mcleod, Morag Charles, Sarah Jane Sutherland, Carol E. Dawson, Paul Mitchell, Alex MacLellan, Sandra Muir, Lynne Johnstone, John O’Connor, Shirley Johnstone, Jim McPherson, Jane Hair, Massimo Pignatelli, Roma A. Armstrong, JEFF EVANS, Margaret Burgoyne, Karen Blessing, Fraser R. Duthie, Colin Moyes, Elizabeth Mallon, David Millan, Fiona Roberts, Morag Seywright, Siobhan Fraser, Ian Ford, Sharon Kean, Marion Flood, David C. Grant, Tom Moffat, Hugh Mclelland, Alistair Kyle, Graham Cameron, Martin C. Wright, S. Kenny, Karen Mcauslan, Andrew D. Jones, T. E. Fitzsimons, Fiona Graham, Alexandra Bell, P. Duffy, A J Fisher, Alexis Smith, E.L. Shannon, Bryan T. Woods, Colin A. Hutchison, Angela Booth, Lyndsay Duffy, Gillian Mcculloch, H. Farouk Sadiq, Susan Deakin, Steven Haywood, John Chester, Alison Parry-Jones, Suzanne Williams, David Griffiths, Fiona J. E. Morgan, Hazel Bailey
4Citations signalées — pas une note de qualité
32Institutions déclarées
1Pays d’affiliation déclarés
Résumé fourni par la source
Introduction Phase I of the Cancer Research UK Stratified Medicine Programme (SMP1) was designed to roll out molecular pathology testing nationwide at the point of cancer diagnosis, as well as facilitate an infrastructure where surplus cancer tissue could be used for research. It offered a non-trial setting to examine common UK cancer genetics in a real-world context. Methods A total of 26 sites in England, Wales and Scotland, recruited samples from 7814 patients for genetic examination between 2011 and 2013. Tumour types involved were breast, colorectal, lung, prostate, ovarian cancer and malignant melanoma. Centralised molecular testing of surplus material from resections or biopsies of primary/metastatic tissue was performed, with samples examined for 3–5 genetic alterations deemed to be of key interest in site-specific cancers by the National Cancer Research Institute Clinical Study groups. Results 10 754 patients (98% of those approached) consented to participate, from which 7814 tumour samples were genetically analysed. In total, 53% had at least one genetic aberration detected. From 1885 patients with lung cancer, KRAS mutation was noted to be highly prevalent in adenocarcinoma (37%). In breast cancer (1873 patients), there was a striking contrast in TP53 mutation incidence between patients with ductal cancer (27.3%) and lobular cancer (3.4%). Vast inter-tumour heterogeneity of colorectal cancer (1550 patients) was observed, including myriad double and triple combinations of genetic aberrations. Significant losses of important clinical information included smoking status in lung cancer and loss of distinction between low-grade and high-grade serous ovarian cancers. Conclusion Nationwide molecular pathology testing in a non-trial setting is feasible. The experience with SMP1 has been used to inform ongoing CRUK flagship programmes such as the CRUK National Lung MATRIX trial and TRACERx.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme
- Date Crossref
- 01/01/2018
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Cancer Genomics and DiagnosticsBRCA gene mutations in cancerGenetic factors in colorectal cancer