P6351Direct comparison of prognostic ability of BNP and NT-proBNP for cardiogenic stroke and clinical outcome in patients with stroke

Résumé fourni par la source

Background: Despite many recent advances in medicine, cardiogenic stroke is still a health problem with a high mortality rate. Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) have been reported to be useful indicators for cardiogenic stroke and subsequent cerebrovascular events. Several reports suggested a difference in prognostic ability for cardiogenic stroke and cerebrovascular events between these biomarkers. However, there are no data directly comparing the two biomarkers in patients with stroke. Aim: The aim of this study was to examine the association of BNP and NT-proBNP with left atrial function and left atrial appendage function and to directly compare the prognostic ability of BNP and NT-proBNP for cardiogenic stroke and major adverse cerebrovascular events (MACE) in patients with stroke. Methods and results: We measured BNP and NT-proBNP levels and performed transthoracic and transesophageal echocardiography in 282 patients with stroke. There were 108 cardiogenic stroke and 47 MACE during the follow-up period of 1,460 days. Both BNP and NT-proBNP levels were significantly associated with left atrial function and left atrial appendage function. Multivariate logistic analysis demonstrated that both biomarkers were significantly associated with cardiogenic stroke in patients with stroke. Additionally, multivariate Cox proportional hazard regression analysis demonstrated that both biomarkers were significantly associated with MACE after adjustment for confounding risk factors. Receiver operating characteristic curve analysis showed the equivalent areas under the curve of both BNP and NT-proBNP for cardiogenic stroke and MACE.

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